Council of Scientific and Industrial Research

Pralay Das

Ajay Kumar

Bikram Singh

Dharminder Sharma

Shaifali

The present invention relates to a new protocol for 'Process development for 5-hydroxymethylfurfural (5-HMF) synthesis from carbohydrates'. A convenient, atom-economic, highly selective and cost-effective process has been developed for the preparation of 5-HMF from cellulose, hemicellulose, starch, different sources of carbohydrates and further extended to glucose and fructose.

Process development for 5-hydroxymethylfurfural (5-HMF) synthesis from carbohydrates

A regio-selective and consecutive Michael-Claisen process has been developed for substituted cyclohexane-1,3-dione synthesis started from unsubstituted or substituted acetone and &#x3b1;,&#x3b2;-unsaturated esters. Substituted cyclohexane-1,3-diones are the basic unit found in several natural products, bioactive alkaloids and acridine dione type heterocycles, polyphenols, and unnatural amino acid synthesis. Most of the potent herbicidal and pesticidal active molecules contain cyclohexane-1,3-dione derivatives. Such an important intermediate synthesis using a facile, atom economy and one-pot process is a demandable area in organic synthesis.

Growing community of inventors

Palampur, India

Pralay Das