Bristol-myers Squibb Compnay

Astrazeneca Ab

Skinmedica, Inc.

Otsuka Pharmaceutical Company, Limited

Stiefel Laboratories, Inc.

Prakash V Parab

Mandar V Dali

Ravindra W Tejwani

Jatin M Patel

Dilbir S Bindra

Nipa Vatsaraj

Li Tao

Yongmei Wu

Bhiku Patel

Cheng Der Yu

Robert Lavker

Joyce T Chou

Joyc Tianw I Chou

James Leyden

Yongemei Wu

Joyce Chou

Pharmaceutical formulations are provided which are in the form of capsules or tablets for oral use and which include a medicament dapagliflozin or its propylene glycol hydrate and a pharmaceutical acceptable carrier therefor, which formulation is designed for immediate release.

Pharmaceutical formulations containing an SGLT2 inhibitor

Polyethylene glycol ethers of alkyl alcohols having the general formula CH(CH)CH(OCHCH)OH wherein x is 8 to 20 (of which ceteareth-20, steareth-20 and steareth-100 are preferred), poloxamer 185, poloxamer 407, N,N-dimethyl dodecylamine N-oxide, and mixtures thereof, are employed to increase follicular delivery and/or follicular residence time of certain water soluble ornithine decarboxylase inhibitors of which 2(difluoromethyl)-2,5-diamino pentanoic acid and its pharmaceutically acceptable salts, hydrates, optical enantiomers and racemic mixture are preferred.

Topical composition for follicular delivery of an ornithine decarboxylase inhibitor

The present invention provides for a pharmaceutical solution suitable for oral administration comprising aripiprazole, a pharmaceutically suitable solvent system, one or more taste-enhancing/masking agents and one or more agents selected from the group consisting of lactic acid, acetic acid, tartaric acid and citric acid, wherein said solution has a pH from 2.5 to 4.5.

Aripiprazole oral solution

A long-term storage stable tretinoin and 4-hydroxyanisole composition contains low molecular weight polyethylene glycol, antioxidant, a chelating agent, lower alkanol and water. The chelating agent provides at least two of the functions of oxygen scavaging, free radical chain terminating and reducing. The composition has a pH of 2.5 to 5 and a water content of at least 12%.

Storage stable tretinoin and 4-hydroxyanisole containing topical composition

The invention provides methods and means for enhancing the epidermal, transdermal and dermal permeation of a topically applied pharmacologically active agent (e.g., a drug or medicament) which has a low rate of skin penetration in the absence of a permeation enhancer and which is unstable and degrades during long-term storage with particular permeation enhancers. Also provided by the invention are methods and means to increase the skin penetration of a pharmacologically active agent which has a normally low rate of skin permeation and causes the instability and degradation of a permeation enhancer with which it is combined over a long period of time. Provided by the invention are at least one first composition containing a drug, a pharmaceutically acceptable salt, chemical derivative or formulation thereof, in a dermatologically acceptable vehicle, and at least one second composition containing a permeation enhancer in an acceptable vehicle. The compositions are physically separated until application to a body or skin surface and are topically applied, either at the same time, or sequentially within a short time of each other, and mixed or blended to form a final active composition, preferably on the skin. In addition, a premixture of the compositions can be made and applied to the skin in accordance with the invention. The invention allows a therapeutically effective amount of drug to be delivered into the skin and systemic circulation and provides significant enhancement of a drug's otherwise low level of skin permeation by the action of permeation enhancer in the active composition at the point of use.

Methods and compositions for enhancing skin permeation of drugs using

The invention provides methods and compositions for improving and reducing age-related skin disorders, particularly fine lines and/or wrinkles, including fine wrinkles, on human skin. The cosmetic compositions of the invention are formulated with less than effective amounts of anti-wrinkle active agents (e.g., drugs) or are devoid of such active agents, which include .alpha.-hydroxy acid and derivatives and salts thereof, tretinoin and derivatives and salts thereof, or vitamin C, and which are typically used for treating and reducing skin lines and/or wrinkles. As tested in clinical trials, the compositions of the invention reduced and improved fine lines and/or wrinkles as well as, or better than, preparations containing .alpha.-hydroxy acids, .alpha.-hydroxy acid salts, tretinoin, or vitamin C, thereby achieving effective anti-wrinkle formulations that are safe, economical and stable, without potential adverse effects to the user that can accompany the use of the aforementioned, typically-employed antiwrinkle preparations and products.

Methods and compositions for fine lines and/or wrinkles

The cutaneous atrophy associated with the use of steroids topically can be ameliorated using salts of certain .alpha.-hydroxyacids.

Reduction of cutaneous atrophy

Methods of increasing the rate of lactic acid permeation in skin for the treatment of dermatological disorders by applying a composition containing an inorganic or organic salt of lactic acid in a dermatologically acceptable composition wherein at least 70% of the lactic acid moiety in the salt is L-lactic acid, and compositions for practicing such methods.

Enhanced permeation of alpha-hydroxy acid enantiomer

Method for enhancing the rate of skin permeation of lactic acid through

New uses of certain substituted pyrido[1,2-a]pyrimidin-4-one anti-allergy drugs are made possible by the provision of clear, stable aqueous solutions of same. The aqueous solutions contain novel combinations of drugs and stabilizers.

New uses of 3-tetrazolo -5,6,7,8- substituted-pyrido (1,2-a)

Methods of enhancing skin permeation and skin retention of .alpha.-hydroxy acids for the treatment of dermatological disorders by applying a composition containing an amphoteric salt of an .alpha.-hydroxy acid, such as lactic, glycolic, citric, tartaric or malic acid and an amino acid, dipepdide, polypeptide or proteins, in a dermatologically acceptable carrier which contains 0.5 to 8% glycerol monocaprylate, 0 to 80% petrolatum and 0 to 30% isopropyl myristrate, the pH of the composition being from 3 to 9, and compositions for practicing such methods.

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New Brunswick, NJ, United States of America

Prakash V Parab