The University of Texas System

William Marsh Rice University

Baylor College of Medicine

The United States Government

Houston Methodist Research Institute

Prakash Dharmalingam

James Mitchell Tour

Thomas Andrew Kent

William Sikkema

Muralidhar L Hegde

Lizanne Nilewski

William Dalmeida, Jr

Joy Mitra

Pavana Dixit Hegde

Paul J Derry

Sankar Mitra

Kimberly Mendoza

Ah-Lim Tsai

Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Graphenic materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.

Acute and chronic mitochondrial electron transport chain dysfunction treatments and graphenic materials for use thereof

Growing community of inventors

Houston, TX, United States of America

Prakash Dharmalingam