Generics (UK) Limited

Prakash Bansode

Bindu Manojkumar

Sandeep G Mekde

Abhay Gaitonde

Dattatraya Shinde

Dattatrey Kokane

Sandeep Sonawane

Dattaatraya Shinde

Sunanda Phadtare

The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.

Process for the introduction of hydroxyethoxy side chain in bosentan

The present invention relates to novel crystalline forms of bosentan and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said crystalline forms and use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris.

Crystalline forms of bosentan

Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.

Polymorphic forms

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Maharashtra, India

Prakash Bansode