Carnegie Mellon University

Scienceplusplease, LLC

University of Pittsburgh

Scienceplusplease LLC, Dba Cerebroscope

Prahlad Menon Gopalakrishna

Nicolas Alexander Alba

Philip M Sauter

Alexander Kharlamov

Stephen Carter Jones

Samuel J Hund

David S Schwartzman

Kerem Pekkan

Eric Singer

Daniel Ryder Ludwig

Nicolas A Alba

The present invention provides systems and methods for detection and diagnosis of concussion and/or acute neurologic injury comprising a portable headwear-based electrode array and computerized control system to automatically and accurately detect cortical spreading depression and acute neurological injury-based peri-infarct depolarization (CSD/PID). The portable headwear-based electrode system is applied to a patient or athlete, and is capable of performing an assessment automatically and with minimal user input. The user display indicates the presence of CSD/PID, gauges its severity and location, and stores the information for future use by medical professionals. The systems and methods of the invention use an instrumented DC-coupled electrode/amplifier array which performs real-time data analysis using unique algorithms to produce a voltage intensity-map revealing the temporally propagating wave depressed voltage across the scalp that originates from a CSD/PID on the brain surface.

Non-invasive systems and methods to detect cortical spreading depression for the detection and assessment of brain injury and concussion

A novel arterial cannula tip includes an elongated body having an expanded four-lobe swirl inducer and a diverging diffuser. The swirl inducer presents micro-scale blood-wetting features that help to enhance the jet or core of the flow of blood sufficiently to delay the onset of turbulence and facilitate a strongly coherent blood outflow jet as it enters the cannulated artery, while the diverging diffuser reduces exit force and promotes and laminar flow which mitigates intimal vascular damage owing to high wall shear stresses at regions of jet impingement. When used in conjunction with an aortic cannula, the device facilitates neuroprotection by way of improved cerebral perfusion.

Cannula tip for an arterial cannula

A method for fusing information related to structural features and characteristics of a biological sample. The resulting fused image may be imported into a surgical navigation technology intra-operatively to aid in surgical interventions by co-registering the fused image with the patient's anatomical features.

System and method for structure-function fusion for surgical interventions

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Pittsburgh, PA, United States of America

Prahlad Menon Gopalakrishna