Novo Nordisk A/s

Novo Nordisk Healthcare Ag

Prafull S Gandhi

Henrik Oestergaard

Ole Hvilsted Olsen

Jens Breinholt

Jianhe Chen

Laust Bruun Johnsen

Rong Zhou

Karina Thorn

Per J Greisen

Mikkel Nors Harndahl

Morten Groenbech Rasch

Haisun Zhu

Bjarne Gram Hansen

Zhiru Yang

Paul L DeAngelis

Carsten Behrens

Anders Svensson

Eva Johansson

Friedrich Michael Haller

The invention relates to a bispecific antibody comprising a first antigen-binding site capable of binding Factor VII(a) and a second antigen-binding site capable of binding TLT-1, pharmaceutical formulations comprising such bispecific antibodies and uses thereof.

Factor VII (FVII(a))/TREM-like transcript 1 (TLT-1) bispecific antibodies

The present invention relates to improved procoagulant antibodies including bispecific antibodies capable of binding to coagulation Factor IX (FIX) or the activated form thereof Factor IXa (FIXa) and optionally Factor X (FX) and the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A.

Procoagulant antibodies

Bispecific antibodies

The present invention relates to multispecific procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes or parts thereof and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A as well as kits, methods of manufacture and methods of use.

The present invention relates to modified coagulation Factor VII polypeptides exhibiting increased resistance to antithrombin inactivation and enhanced proteolytic activity. The present invention also relates to polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing such polynucleotides, pharmaceutical compositions, uses and methods of treatment.

Coagulation factor VII polypeptides

Growing community of inventors

Ballerup, Denmark

Prafull S Gandhi