Cubist Pharmaceuticals, Incorporated

Merck Sharp + Dohme Corp.

Pradip M Pathare

Valdas Jurkauskas

Jan-Ji Lai

Jian-Qiao Gu

Joseph Terracciano

Nicole Miller Damour

Kristos Adrian Moshos

You Seok Hwang

Sudhakar Devidasrao Garad

Carlos Lopez

Laxma Kolla

Adrien F Soret

This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized compositions of ceftolozane. Provided herein are salt forms of ceftolozane, processes for making these salt forms and compositions comprising the same. The salt forms provided herein include ceftolozane bromide, ceftolozane edisylate, ceftolozane mesylate, ceftolozane chloride, ceftolozane sulfate, ceftolozane maleate, ceftolozane phosphate, and ceftolozane ketoglutarate.

Salt forms of ceftolozane

Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.

Cephalosporin compositions and methods of manufacture

This disclosure provides compositions containing solid forms of tazobactam arginine, and methods of manufacturing and using these compositions.

Tazobactam arginine compositions

Growing community of inventors

Lexington, MA, United States of America

Pradip M Pathare