Dr. Reddy's Laboratories, Incorporated

Other

Pradip Kumar Sasmal

Ashok Tehim

Vidyadhar Madhav Paradkar

Shahadat Ahmed

Prasanna M Dattatreya

Nanjegowda Jagadeesh Mavinahalli

Vijay Potluri

Yonghua Gai

Hang Zhang

Chintakunta Vamseekrishna

Ganesh Prabhu

Marahanakuli Prasanna Dattatreya

Nanjegowda Jagadeesh Mavinhalli

Ranjan Chakrabarti

Javed Iqbal

Ish Khanna

Saibal Kumar Das

Parimal Misra

Thomas Hogberg

Vamsee Krishna Chintakunta

Thomas Michael Frimurer

Lars-Ole Gerlach

Rashmi Talwar

Mahaboobi Jaleel

Oystein Rist

Lisbeth Elster

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors

The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. wherein R, R, R, R, R, and Rare as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (&#x3ba;) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS.

Substituted heterocyclic acetamides as kappa opioid receptor (KOR) agonists

Substituted pyrazolo[1,5-A] pyridine as tropomyosin receptor kinase (TrK) inhibitors

The present application relates to a series of substituted imidazo[1,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Substituted imidazo[1,2-a]pyridine compounds as tropomyosin receptor kinase a (TrkA) inhibitors

The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts, wherein R, R, R, R, R, and Rare as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (&#x3ba;) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS. 

The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. (I) Wherein A, m, R1s, R2, R3, R4 are as defined herein. This invention also relates to methods of making these compounds including intermediates. The compounds of this invention are effective at the kappa (&#x3ba;) opioid receptor (KOR) site. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic pain, and associated disorders, particularly functioning peripherally at the CNS. 

Kappa opioid receptor agonists

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds

Substituted heterocyclic compounds as tropomyosin receptor kinase a (TrkA) inhibitors

The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5'-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.

Thiazoles derivatives as AMPK activator

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Hyderabad Telangana, India

Pradip Kumar Sasmal