Fuisz Technologies Ltd.

Other

Biovail Technologies Ltd.

Fuisz International Ltd.

Biovail Laboratories International S.r.l.

Pradeepkumar P Sanghvi

Tushar K Misra

Michael G Raiden

John R Sisak

Satish V Kamath

Richard C Fuisz

Steven E Frisbee

Jeffery W Currington

Scott J Szedlock

Djelila Mezaache

Barbara Montwill

Subraman R Cherukuri

Henry Z Hofer

James E Swon

Mark R Herman

David P Prior

Mahendra Govind Pankhania

Joseph Cascone

Amy C Little

Bernard M Kiernan

John Getz

Joan Fitzpatrick

Nils Ahlgren

Michael Myers

Desiree Pereira

Ed O'Donnell

Charles C Collins

John J Getz

David V Prior

Jeffrey W Currington

The invention deals with the use of low temperature and low humidity conditions during the storage and shaping of &ldquo;flash-dose&rdquo; tablet compositions. The compositions may be rendered substantially non-amorphous before tablet formation.

Easily processed tablet compositions

Bioaffecting sachets, or powders, containing coated liquiflash microspheres and partially recrystallized shearform floss particles are disclosed. The sachets give organoleptically acceptable properties, including a pleasing mouthfeel, when orally ingested.

Sachet formulations

The invention relates to compositions useful for making taste-masked oral dosage forms which can be easily processed and which disintegrate rapidly when placed in the mouth. The compositions include coated liquiflash particles and shearform floss particles. Tablets are preferred dosage forms.

Dosage forms containing taste masked active agents

The thermoforming of compositions containing active agents is carried out by processing compositions containing certain fatty esters in combination.

Fatty ester combinations

Lipid lowering dosage units, to be used once a day, produce minimal side effects. They contain a combination of microspheres formulated to co-deliver a HMG-CoA reductase inhibitor component and a niacin component.

Controlled release compositions and methods for the treatment of

The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly in the mouth with optional chewing. The compositions typically include shearform matrices which have been recrystallized using crystallization promoters.

Fast-dissolving comestible units formed under high-speed/high-pressure

A self-binding, glycerine-free tablettable composition has a saccharide carrier and the sugar alcohols sorbitol and xylitol.

Self-binding shearform compositions

The invention relates to a novel dosage unit for the sustained-release delivery of active agents as well as compositions and methods for making same.

Dosage units

The present invention deals with compositions and methods for preparing comestible units which disperse quickly in the mouth, especially when chewed. The present invention also includes the product made therefrom. The method includes initiating crystallization of shearform matrix with crystallization/bindig promoter and combining it with an additive to form flowable, compactible micro-particulates. The combination is then shaped to form a comestible unit having high structural integrity, good appearance, and excellent release characteristics.

Process for forming chewable quickly dispersing comestible unit and

Controlled release dosage units containing water soluble active agents can be made using an active agent, an optional inert carrier, a cellulosic polymer and a lipophilic ingredient.

Controlled release dosage forms containing water soluble drugs

Shearform compositions made without added glycerine are disclosed. The compositions are self-binding and exhibit excellent cohesivity when used in tableting compositions. Typically, xylitol is incorporated into a feedstock which is flash-flow processed to form a self-binding shearform matrix.

In a transdermal cell, a matter volume-adjustment male device includes the lower opening end of the through-space structure having inner wall female threads mateable with first male threads of a screwable matter volume-adjustment male member alternately adjustable upwardly and downwardly between opposite upper and lower female threads-termination points. The screwable matter volume-adjustment member has opposite first upper and lower male threads-termination points, and the inner wall female threads are further concurrently mateable with a bottom closure member having second male threads having opposite second upper and lower male threads-termination points. There is a first annular sealing ring sealably mounted in an annular groove around the screwable volume-adjustment male member between the first upper and lower threads-termination points positioned between the inner wall female threads and the first male threads, and there being a second annular sealing ring sealably mounted the second male threads at a location below the second upper termination point.

Growing community of inventors

Herndon, VA, United States of America

Pradeepkumar P Sanghvi