Lupin, Inc.

Pradeep Rangrao Patil

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Milind Dattatraya Sindkhedkar

Vidya Ramdas

Manojkumar Ramprasad Shukla

Prathap Sreedharan Nair

Samiron Phukan

Rajeshkumar Maganlal Loriya

Talha Hussain Khan

Amit Kumar Das

Deepak Sahebrao Walke

Nilesh Raghunath Khedkar

Sanjay Pralhad Kurhade

Sachin Sethi

Advait Arun Joshi

Moloy Manoj Banerjee

Ganesh Navinchandra Gote

Vaibhav Madhukar Kalhapure

Laxmikant Shamlal Datrange

Dagadu Dube

Vikas Sitaram Tambe

Pradip Balu Wagh

Sudhakar Maruti Balgude

Ganesh Kakade

Vipul Pachpute

Sachin Mahangare

Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, Rto R, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

Substituted tricyclic compounds

The present invention relates to sulfonamide compounds Formula (I) wherein the substituents are as described herein, and their use in a medicine for the treatment of diseases, disorders associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly Na1.7. It further relates to the compounds herein and their pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof useful in treating diseases, disorders, syndromes and/or conditions associated with the inhibition of Voltage-gated sodium channels (VGSC) particularly Na1.7. The invention also relates to process for the preparation of the compounds of the invention. 

Sulfonamide compounds as voltage-gated sodium channel modulators

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Pune, India

Pradeep Rangrao Patil