Rutgers, the State University of New Jersey

Princeton University

Prabhas V Moghe

Kathryn Elizabeth Uhrich

Richard E Riman

Charles M Roth

Mei-Chee Tan

Dominik J Naczynski

Robert K Prud'homme

Yingyue Zhang

Li Gu

Marian Guelakis

Dawanne E Poree

Adam W York

Ram Sharma

Dalia Abdelhamid

Disclosed is a method of non-invasive infrared imaging, comprising (a) administering a composition containing infrared-emitting particles which contain rare earth elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles; and (b) irradiating with infrared radiation, where both excitation and emission spectra of the encapsulated particles are in the infrared region. Analogous methods of image-guided biomedical intervention, and drug tracking and delivery are also disclosed. Also disclosed is a composition for biomedical applications, containing infrared-emitting particles which contain rare earth-elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles.

Multifunctional infrared-emitting composites

The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors.

Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity

Certain embodiments of the invention provide a compound of formula (I):A-X&#x2014;Y&#x2014;Z&#x2014;R&#x2003;&#x2003;(I),or a salt thereof, wherein A, X, Y, Z and Rhave any of the values defined in the specification, and methods of use thereof. For example, certain embodiments of the invention provide a method for inhibiting atherosclerosis or atherosclerotic development in a mammal, comprising administering to the mammal an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.

Amphiphilic macromolecules and methods of use thereof

The invention includes compounds of the formula I and formula II and salts thereof, as well as methods for using the compounds of formula I and formula II for treating atherosclerosis. The invention also includes compounds of formula III and (2l) and salts thereof, as well as methods of using the compounds of formula III and (2l) for treating atherosclerosis. The invention also includes methods of encapsulating molecules using the compounds of the invention.

Macromolecules for treating atherosclerosis

Compositions, methods, and kits for repair and production of extracellular matrix are provided. In the broad aspect, the composition comprises a ligand of &#x3b1;5&#x3b2;1 integrin attached to a surface of a nanoparticle composed of a protein, with a proviso that the protein is not fibronectin.

Extracellular matrix production from nanoscale substrate

Growing community of inventors

Basking Ridge, NJ, United States of America

Prabhas V Moghe