Hoffmann-la Roche Inc.

Other

Prabhakar R Sheth

Jacques L Tossounian

Harold Leon Newmark

William Joseph Mergens

Surendra Anandrao Sangekar

A novel method of manufacturing a novel effective antihypertensive, diuretic and antihypokalemic pharmaceutical composition in which a triamterene active pteridine, a hydrochlorothiazide active benzothiadiazide, and a filler are thoroughly mixed with a polyethylene glycol, applying heat to the melting point thereof when the mixture instantaneously fuses to form granules, while cooled, then the granules are formulated into effective dosage units.

Method of manufacturing an antihypertensive, diuretic and

The effect of a controlled release, hydrodynamically balanced dosage formulation containing both an aqueous phase N-nitroso compound blocking agent and a lipid phase N-nitroso compound blocking agent in preventing the formation of nitrosamines and nitrosamides in the stomach is disclosed.

Prevention of N-nitroso compound formation in vivo

Hydrodynamically balanced controlled release compositions for the preparation of pharmaceutical capsules or tablets which contain L-Dopa and a decarboxylase inhibitor and which provide superior blood levels of L-Dopa are disclosed.

Hydrodynamically balanced controlled release compositions containing

A novel sustained release formulation for the preparation of tablets for oral administration is disclosed. The formulation is hydrodynamically balanced to be buoyant in gastric juice thereby remaining in the stomach for an extended period of time.

Novel sustained release tablet formulations

Sustained release tablet formulations

Sustained release pharmaceutical capsules suitable for oral administration and particularly suitable for sustained release therapy with certain benzodiazepines, e.g. chlordiazepoxide and diazepam, are disclosed. The formulation contained in the disclosed capsules is hydrodynamically balanced to be buoyant in gastric fluid thereby remaining buoyant in the gastric fluid until substantially all of the medicament therein has been released.

Sustained release pharmaceutical capsules

Improved pharmaceutical lubricants comprising finely divided magnesium or calcium stearate coated with a surfactant are disclosed. The improved lubricants greatly enhance disintegration and dissolution time of tablets and capsules prepared therefrom without loss in essential pharmaceutical lubricant properties.

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Pearl River, NY, United States of America

Prabhakar R Sheth