Kyowa Hakko Kirin Co., Limited

Kirin Beer Kabushiki Kaisha

Kirin Holdings Kabushiki Kaisha

Poothappillai Kasinathan

Isao Ishida

Kazuma Tomizuka

James M Robl

Yoshimi Kuroiwa

Barbara A Osborne

Richard A Goldsby

Philippe Collas

Eddie Sullivan

In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or prion protein.

Method of producing xenogenous antibodies using a bovine

The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.

Transgenic ungulates capable of human antibody production

Transgenic animals and uses thereof

Transgenic bovines capable of human antibody production

Growing community of inventors

Sioux Falls, SD, United States of America

Poothappillai Kasinathan