Biocryst Pharmaceuticals, Inc.

University of Louisville Research Foundation, Inc.

Advanced Cancer Therapeutics, LLC

Gb Act, Inc.

Pooran Chand

Yarlagadda Sudhakara Babu

Pravin L Kotian

Minwan Wu

V Satish Kumar

Yahya El-Kattan

Gilles Hugues Tapolsky

Shanta Bantia

Shane Arnold

John Michael Kilpatrick

Tsu-Hsing Lin

John Olaf Trent

Ajit K Ghosh

John A Montgomery

Sucheta Telang

Jason Chesney

Brian F Clem

R Scott Rowland

Shri Niwas

Arthur J Elliott

David A Walsh

Robert A Mitchell

Scott R Rowland

The invention provides unit dosage forms, kits, and methods useful for treating viral infections.

Antiviral treatments

A novel compound, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one, is provided herein. (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) with surprisingly superior efficacy and pharmacodynamic properties in vitro and in vivo. Also provided are pharmaceutical compositions including the compound and methods of use of the compound in treating cancer and tumors in vivo, as well as inhibiting glycolytic flux and PFKFB3 enzymatic activity in cells. 

PFKFB3 inhibit and methods of use as an anti-cancer therapeutic

The invention provides unit dosage forms, kits, and methods and useful for treating viral infections.

PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic

Small molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) having the following formula: Formula (1) are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting PFK.FB3 enzymatic activity, methods of inhibiting glycolytic flux, and methods of treating tumors by administering an effective amount of a Formula I compound. 

Small molecule inhibitors of PFKFB3 and glycolytic flux and their methods of use as anti-cancer therapeutics

Small molecule choline kinase inhibitors, pharmaceutical compositions thereof, and screening methods for identifying and evaluating choline kinase inhibitors are provided. Safe and effective methods for treating subjects suffering from a disorder or disease characterized by neoplastic cell proliferation employing the choline kinase inhibitors are also provided.

Small molecule choline kinase inhibitors, screening assays, and methods for treatment of neoplastic disorders

Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound. 

Iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (MIF)-implicated diseases and conditions

A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.

Family of PFKFB3 inhibitors with anti-neoplastic activities

The invention provides compounds of Formula (I), as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of Formula (I) are useful as anti-viral agents and/or as anti-cancer agents. 

Antiviral nucleoside analogs

Methods for the preparation of the &#x3b2; isomer of a 9-deazapurine derivatives using benzyl protecting groups as the protecting groups for the 2 and 3 hydroxyl groups in ribose are provided.

Methods for the preparation of 9-deazapurine derivatives

The invention provides compounds of formula (I), as described herein, or pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula (I) are useful as anti-viral agents and/or as anti-cancer agents.

Tetrahydrofuro [3,4-D] dioxolane compounds for use in the treatment of viral infections and cancer

The invention provides methods for treating hepatitis C viral infections and related viral infections, as well as compounds and compositions that are useful for treating such infections.

Growing community of inventors

Birmingham, AL, United States of America

Pooran Chand