Other

Nri R&d Patent Licensing, LLC

Pooncharas Tipgunlakant

Lester Frank Ludwig

Alice Huang

Karen Hao

Frank Hu

Cap arrangements for per-well fluidics and gas exchange for microplate, microtiter, and microarray technologies are presented for use with cell cultures or other applications. In example implementations, each individual well within in a conventional or specialized microplate can be fully or partially isolated with capping or other arrangements which can include conduits for controlled introduction, removal, and/or exchange of fluids and/or gases. Conduit networks can include small controllable valves that operate under software control, and micro-scale pumps can also be included. Conduit interconnections can include one or more of controllable-valve distribution buses, next-neighbor interconnections, and other active or passive interconnection topologies. Cap arrangements within the lid can include or provide one or more sensors of various types, including but not limited to selective gas sensors, chemical sensors, temperature sensors, pH sensors, biosensors, immunosensors, molecular-imprint sensors, optical sensors, fluorescence sensors, bioFETS, etc. Incubator interfacing and imaging are described.

Cap arrangements providing per-well fluidics and gas exchange for advanced microplate, microarray, and microtiter technologies

Optical tomography arrangements are disclosed for performing optical tomography on the transparent or translucent contents of individual microplate wells comprising a light emitting array having a plurality of light emitting elements, a sample module, and a light sensing array including a plurality of light sensing elements, wherein the light sensing array is configured to sense light emitted from the light emitting array which has passed through the sample module. The light emitting elements can comprise light emitting diodes (LEDs), organic light emitting diodes (OLEDs), organic light emitting transistors (OLETs), and/or other optoelectronic devices. The light sensing array can comprise organic light sensing devices, photodiodes, phototransistors, CMOS photodetectors, or charge-coupled devices (CCDs). The light emitting array can be flat or curved, and the light sensing array can be flat or curved. The collection of measurement values can be overspecified, and a generalized inverse operation can provide solutions rendering computational tomography data.

Optical tomography optoelectronic arrangements for microplate wells

A color optical tomography system with fluorescence capabilities includes a light emitting array having a plurality of light emitting elements, a sample module, and a light sensing array including a plurality of light sensing elements, wherein the light sensing array is configured to sense light emitted from the light emitting array which has passed through the sample module. Light emitting elements emitting in the visible and UV ranges can comprise light emitting diodes (LEDs), organic light emitting diodes (OLEDs), organic light emitting transistors (OLETs), and/or other optoelectronic devices. The light sensing array can comprise for example organic light sensing devices, photodiodes, phototransistors, a CMOS photodetector, and/or charge-coupled devices (CCI)s). The light emitting array and the light sensing array can he flat or curved. The collection of measurement values can he overspecified, and a generalized inverse operation can be used to provide a solution to a resulting overspecified system of equations.

Optical tomography optoelectronic arrangements for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications

The invention provides a platform technology with rich ability to flexibly perform, create, deploy, maintain, and update a wide range of panels, assay, array, and/or sequence of tests for a wide range of substances and pathogens. The invention provides a unifying framework for widely-ranging miniature sensor implementation, fluidic/gas interfacing, electrical interfaces and optical interfaces, and further by collocating, allowing the integration a large number highly-selective sensors and chemical sensors&#x2014;together as needed with appropriately selected supplemental sensors (for example temperature, pH, selective ions, etc.), into a common readily-manufacturable framework. The diverse sensor arrays give rise to statistical enhancing through novel statistical processing approaches. The invention is deployable and useable in a wide range of situations previously unavailable, and addresses many otherwise problematic aspects of field testing for food safety, water safety, epidemic outbreaks, routine diagnosis, and disease monitoring.

Microprocessor-controlled microfluidic platform for pathogen, toxin, biomarker, and chemical detection with removable updatable sensor array for food and water safety, medical, and laboratory applications

A cylindrical optical tomography system includes a light emitting array having a plurality of light emitting elements, a cylindrical sample holding element, and a light sensing array including a plurality of light sensing elements, wherein the light sensing array is configured to sense light emitted from the light emitting array which has passed through the sample holding module.

Cylindrical optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications

Arrangements for per-well fluidics, gas exchange, and electronic sensors for microplate, microtiter, and microarray technologies are presented. In example implementations, each individual well within in a conventional or specialized microplate can be fully or partially isolated with capping or other arrangements which can include conduits for controlled introduction, removal, and/or exchange of fluids and/or gases. Conduit networks can include small controllable valves that operate under software control, and micro-scale pumps can also be included. Conduit interconnections can include one or more of controllable-valve distribution buses, next-neighbor interconnections, and other active or passive interconnection topologies. Cap arrangements can include or provide one or more sensors of various types, including but not limited to selective gas sensors, chemical sensors, temperature sensors, pH sensors, biosensors, immunosensors, molecular-imprint sensors, optical sensors, fluorescence sensors, bioFETS, etc. Incubator interfacing and imaging are also described. The invention can be used for living cell culture or other applications.

Advanced microplate, microtiter, and microarray technologies with per-well fluidics, gas exchange, electronic sensors, and imaging for cell culture and other applications

An optical tomography system including a light emitting array having one or more light emitting diodes (LEDs), a sample holding module and a light sensing array comprising one or more light emitting diodes (LEDs), wherein the light sensing array is configured to sense light emitted from the light emitting array, which has passed through the sample holding module.

Optical tomography for microscopy, cell cytometry, microplate array instrumentation, crystallography, and other applications

An electronic imaging flow-microscope for remote environmental sensing, bioreactor process monitoring, and optical microscopic tomography applications is described. A fluid conduit has a port on each end of a thin flat transparent fluid transport region. A planar illumination surface contacts one flat side of the transparent fluid transport region and a planar image sensing surface contacts the other flat side. Light from the illumination surface travels through the transparent fluid transport region to the planar image sensing surface, producing a light field affected by the fluid and objects present. The planar image sensing surface creates electrical image signals responsive to the light field. The planar illumination surface can be light emitting elements such as LEDs, OLEDs, or OLET. whose illumination can be sequenced in an image formation process. The flow microscope can further comprise flow-restricting valves, pumps, energy harvesting arrangements, and power management.

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San Francisco, CA, United States of America

Pooncharas Tipgunlakant