National Institutes of Health, a Component of the US Dept. of Health & Human Services

Arizona Board of Regents on Behalf of the University of Arizona

Poonam Tewary

Thomas Joseph Sayers

Alan David Brooks

Leslie Gunatilaka

Kithsiri Wijeratne

James Brislin McMahon

Curtis J Henrich

Yaming Xu

Ya-Ming Xu

Disclosed are compounds suitable for enhancing cancer treatment, for example, a compound of formula (I): (I) wherein Ris as defined herein. Also disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, a method of inducing apoptosis in cancer cells in a mammal, and a method of treating prostate cancer in mammal in need thereof comprising administration of a compound described herein.

17-beta-hydroxywithanolides and use thereof in treating cancer

Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R-Rare as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells. 

Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment

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Frederick, MD, United States of America

Poonam Tewary