National Institutes of Health, a Component of the US Dept. of Health & Human Services

Virginia Tech Intellectual Properties, Inc.

Polly Matzinger

William Hugold Velander

Oral Alpan

Tirumalai Kamala

John Paul Ridge

Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.

Induction of tolerance by oral administration of factor VIII and treatment of hemophilia

Oral treatment of hemophilia

The present invention relates to the identification of candidate ligands which modulate antigen presenting cells. Specifically, ligands which superactivate antigen presenting cells are identified.

Identification of candidate ligands which modulate antigen presenting cells

Growing community of inventors

Bethesda, MD, United States of America

Polly Matzinger