Imec Vzw

Katholieke Universiteit Leuven, Ku Leuven R&d

Imec

Katholieke Universiteit Leuven

Panasonic Corporation

Midiagnostics Nv

Pol Van Dorpe

Liesbet Lagae

Peter Peumans

Tim Stakenborg

Willem Van Roy

Niels Verellen

Chang Chen

Gustaaf Regina Borghs

Kai Cheng

Iwijn De Vlaminck

Xavier Rottenberg

Masahiko Shioi

Simone Severi

Koen Martens

Dries Vercruysse

Kristof Lodewijks

Finub James Shirley

Jian Ye

Anne S Verhulst

Richard Stahl

Tom Claes

Philippe Soussan

Karolien Jans

Jeonghwan Song

Andim Stassen

Bert Du Bois

Dmitry Kouznetsov

Hilde Jans

Sarp Kerman

Philippe Helin

Gabrielle Woronoff

Jiaqi Li

Pieter Neutens

Willem Jozef Katharina Van Roy

Giuseppe Fiorentino

A sensor is provided. The sensor includes a field effect transistor comprising: an active region comprising a source region, a drain region, and a channel region between the source region and the drain region; a dielectric region on the channel region; an enzyme coupled to the dielectric region, the enzyme having an active site for interacting with a substrate; an electrolyte-screening layer coupled to the dielectric region, covering part of the enzyme while leaving the active site uncovered, thereby permitting interaction of the substrate with the active site, and a fluidic gate region to which the active site of the enzyme is exposed. A biosensing device including one or more of the sensors is also provided.

Field-effect transistor-based biosensor

A method of operating a pore field-effect transistor (FET) sensor for detecting particles, wherein the pore FET sensor comprises a FET wherein a gate is controlled by a pore filled by a fluid, comprises: controlling a first voltage (V) to set the FET in a subthreshold region; controlling a second voltage (V) to set a voltage difference between the first and second voltages (V) such that an effective difference in gate voltage experienced between a minimum and a maximum effective gate voltage during movement of a particle in the fluid is at least kT/q; and detecting a drain-source current in the FET, wherein the particle passing through the pore modulates the drain-source current for detecting presence of the particle.

Method of operating a pore field-effect transistor sensor for detecting particles

According to an aspect of the present inventive concept there is provided a light excitation and collection device for a micro-fluidic system, comprising:

Light excitation and collection device and a method for light excitation and collection

The present invention provides an apparatus for detecting photoluminescent light emitted from a sample, said apparatus () comprising at least one light source (), which is configured to emit light of a first and a second wavelength towards a sample comprising photoluminescent particles, wherein said first wavelength is an excitation wavelength for inducing photoluminescent light from said photoluminescent particles, and wherein said second wavelength is longer than said first wavelength and for gathering background noise information from said sample. The apparatus further comprises a photo-detector () for detecting light incident on the photo-detector (); and an interference filter () arranged on the photo-detector (), wherein the interference filter () is configured to selectively collect and transmit light towards the photo-detector () based on an angle of incidence of the light towards the interference filter (), wherein the interference filter () is configured to selectively transmit supercritical angle light from the sample towards the photo-detector () and suppress undercritical angle light from the sample.

Apparatus and method for detecting photoluminescent light emitted from a sample

An illuminator, comprising: an illumination waveguide, and a controller; the illumination waveguide being a planar waveguide configured to receive a light wave at a receiving end and guide it to a mirror end; the mirror end comprising a patterned mirror configured to reflect at least part of the light wave back into the illumination waveguide, the patterned mirror comprising a pattern configured to confer a diffraction pattern to the reflected light, the diffraction pattern contributing to an interference pattern, the interference pattern having an evanescent field outside the illumination waveguide, wherein the evanescent field of the interference pattern is configured to illuminate an object in close relation to the illumination waveguide; wherein the controller is configured to control a wavefront of the received light wave and to set a relation between the controlled wavefront and the pattern of the patterned mirror such that the interference pattern forms at least one element of constructive interference for selectively illuminating a portion of the object; wherein the controller is further configured to sequentially change the interference pattern.

Illuminator, an imaging apparatus and a system

Example embodiments relate to methods and devices for generating (quasi-) periodic interference patterns. One embodiment includes a method for generating an interference pattern using multi-beam interference of electromagnetic radiation. The method includes computing a set of grid points in a complex plane representing a grid with a desired symmetry. The method also includes selecting a radius of a virtual circle. Additionally, the method includes selecting a set of grid points in the complex plane that lies on the virtual circle centered around a virtual center point. Further, the method includes associating an argument of each grid point of the selected set of grid points in the complex plane with a propagation direction of plane waves or quasi plane waves or parallel wave fronts. In addition, the method includes obtaining the interference pattern that is a superposition of the plane waves or quasi plane waves or parallel wave fronts.

Method and device for generating (quasi-) periodic interference patterns

An apparatus for detecting fluorescent light emitted from a sample comprises: a light source, which is configured to emit excitation light of an excitation wavelength towards a sample comprising fluorophores such that fluorescent light is induced; a photo-detector for detecting light incident on the photo-detector; and an interference filter arranged on the photo-detector, wherein the interference filter is configured to selectively collect and transmit light towards the photo-detector based on an angle of incidence of the light towards the interference filter, wherein the interference filter is configured to selectively transmit supercritical angle fluorescence from the sample towards the photo-detector and suppress undercritical angle fluorescence from the sample.

Apparatus for detecting fluorescent light emitted from a sample, a biosensor system, and a detector for detecting supercritical angle fluorescent light

In a first aspect, the present invention relates to a nanopore field-effect transistor sensor (), comprising: i) a source region () and a drain region (), defining a source-drain axis; ii) a channel region () between the source region () and the drain region (); iii) a nanopore (), defined as an opening in the channel region () which completely crosses through the channel region (), oriented at an angle to the source-drain axis, having a first orifice () and a second orifice (), and being adapted for creating a non-linear potential profile between the first () and second () orifice.

Nanopore FET sensor with non-linear potential profile

The present disclosure relates to a spectral sensor for detection of individual light-emitting particles. The sensor is comprising an array of photo-sensitive detectors for detecting light emitted by said individual light-emitting particles and a filter array comprising a plurality of different band-stop filters. The filter array is configured to transmit wavelengths in a detectable wavelength region to the array of photo-sensitive detectors, and wherein each band-stop filter is associated with one or more particular photo-sensitive detectors, and the plurality of different band-stop filters are configured to reflect different wavelength intervals within said detectable wavelength region so that each photo-sensitive detector of the array is configured to detect the wavelengths of the detectable wavelength region other than the reflected wavelength interval of the band-stop filter being associated with the photo-sensitive detector. The sensor is further comprising a processing unit in communication with said array of photo-sensitive detectors and configured for determining a spectral characteristic of an individual light-emitting particle based on the response from said array of photo-sensitive detectors.

Multicolor sensor for flow cytometry

The present disclosure relates to devices and methods for non-invasive measuring of analytes. At least one embodiment relates to a wearable system for non-invasive measuring of a concentration of an analyte in skin tissue. The wearable system includes an integrated circuit that includes a first optical unit. The first optical unit includes a Raman spectrometer. The first optical unit also includes an OCT spectrometer and an interferometer optically coupled to the OCT spectrometer or an infrared (IR) spectrometer. The first optical unit additionally includes a light coupler. The wearable system further includes a first light source for performing Raman spectroscopy. The wearable system additionally includes a second light source for performing OCT spectroscopy or IR spectroscopy. Still further, the wearable system includes read-out electronics to determine an optical model of the skin tissue based on the spectroscopic data and to determine the concentration of the analyte.

Device and method for non-invasive measuring of analytes

A sensor device for quantifying luminescent targets comprises a light source, a detector, a modulator, and a processor. The light source is adapted for exciting the luminescent target. The detector is adapted for detecting the luminescence of the luminescent target resulting in a measured signal which comprises a desired signal originating from the luminescent target and a background signal. The modulator is adapted for modulating a physical parameter resulting in a modulation of the desired signal which is different from the modulation of the background signal. The processor is configured to correlate the modulation of the physical parameter with the modulation of the desired signal and/or the modulation of the background signal.

Modulation of luminescent dyes

An imaging apparatus comprises: (i) an illumination waveguide configured to propagate light by total internal reflection, wherein an evanescent field illuminates an object in close relation to the illumination waveguide; (ii) an array of light-sensitive areas arranged on a common substrate with the illumination waveguide for detecting light from the object; and (iii) a controller configured to control forming of an interference pattern in the illumination waveguide, wherein the interference pattern comprises at least one element of constructive interference for selectively illuminating a portion of the object, the at least one element having a dimension with a size in a range of 100 nm-10 &#x3bc;m; wherein the controller is configured to sequentially change the interference pattern in relation to the object such that different portions are illuminated and light from different portions is sequentially detected.

Imaging apparatus and method for imaging an object

Sensor devices for quantifying luminescent targets are described herein. An example device comprises a light source for exciting the targets, thus generating luminescence signals and a detector for detecting these signals, resulting in a detected signal which comprises a desired signal originating from the targets and a background signal. It moreover comprises a bleaching device for bleaching of at least part of the sources generating the background signal and a processor configured to trigger the bleaching device to start bleaching, and to trigger the light source for exciting the remaining luminescent targets which are not bleached, and to trigger the detector for detecting the luminescence signal of the remaining luminescent targets, so as to generate a measurement signal representative for the quantification of the luminescent targets.

Bleaching of dyes in luminescent detection

A sensor device for quantifying luminescent targets configured in an at least one dimensional pattern. The sensor device comprises a detector for obtaining an at least one dimensional pattern of measured signals, wherein the detector is adapted for detecting the luminescence of the luminescent targets, resulting in a measured pattern. The sensor device moreover comprises a processor configured to correlate the measured pattern with at least one reference pattern, so as to generate a measurement signal representative for the quantification of luminescent targets. The at least one reference pattern is a recorded pattern or an expected pattern. A recorded pattern is a pattern which is obtained by the detector before the measured pattern is obtained.

Quantification of topologically arranged luminescent dyes

There is provided an optical system for coupling light into a waveguide. The optical system comprising a coupler arranged at a portion of the waveguide. The coupler has a surface with a grating structure for directing light into the waveguide formed therein. A cladding layer embeds the coupler and an optical path changing structure is formed in the cladding layer. The optical path changing structure has a refractive surface and a reflective surface, each forming an acute angle with respect to the surface of the coupler. Light which enters the optical path changing structure through the refractive surface will be refracted and directed towards the reflective surface. The reflective surface is arranged to reflect the light such that it is directed towards the grating structure of the coupler along a direction suitable for efficient coupling of light into the waveguide.

Growing community of inventors

Spalbeek, Belgium

Pol Van Dorpe