Taipei Medical University

Changhua Christian Medical Foundation Changhua Christian Hospital

National Research Institute of Chinese Medicine, Ministry of Health and Welfare

Po-Li Wei

Chia-Hwa Lee

Yuan-Soon Ho

Ching-Shyang Chen

Li-Ching Chen

Yu-Jia Chang

Shih-Hsin Tu

Ying-Jan Wang

Ching-Shui Huang

Chih-Hsiung Wu

Shiow-Lin Pan

Yu-Ching Lee

Keng-Chang Tsai

Hui-Wen Chang

Ka-Wai Tam

Tzu-Chun Cheng

Jan-Show Chu

Wei-Chun Huangfu

Tsui-Chin Huang

Han-Li Huang

Chun-Chun Cheng

Cheng-Chiao Huang

Kun-Tu Yeh

Ting-Yi Sung

Chien-Hsi Chang

Fu-Ling Chang

Ya-Chieh Chang

The invention relates to anti-EGF like domain multiple 6 antibody (anti-EGFL6 antibody) and cancer detection (or diagnosis) and treatment using the anti-EGFL6 antibody. The present invention creates anti-EGFL6 antibodies, particularly, a single-chain antibody fragments (scFv) and humanized antibody, which have ability in binding to EGFL6 and in inhibiting angiogenesis and cancer cell growth.

Anti-EGF like domain multiple 6 (EGFL6) antibodies

The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or &#x3b1;9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that &#x3b1;9-nAChR has an activating protein 1 (AP1)-binding site, that the &#x3b1;9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the &#x3b1;9-nAChR promoter at the AP1-binding site, indicating that ER-induced &#x3b1;9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.

Method of identifying a candidate compound which may inhibit &#x3b1;9-nAchR overexpression or estrogen receptor-dependent transcription in nicotine-derived-compound-induced breast cancer cells

The invention found that overexpression and activation of &#x3b1;9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of &#x3b1;9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of &#x3b1;9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.

Small interfering RNAs and methods for prevention, inhibition and/or treatment of malignant progression of breast cancer

Growing community of inventors

Taipei, Taiwan

Po-Li Wei