Industrial Technology Research Institute

Nuvasive, Inc.

Po-Hung Lai

Chih-Peng Liu

Tsan-Lin Hu

Maggie J M Lu

Chia-Mu Tu

Min-Ying Lin

Ali Ismailoglu

Sung-Ching Chen

Shuen-Hsiang Chou

Yu-Wen Lo

Kehsin Chien

Chia-Wen Huang

Frank Vizesi

The disclosure provides a pharmaceutical composition. The pharmaceutical composition includes a chitosan with palmitoyl groups and an active agent. According to another embodiment, the pharmaceutical composition can further include a gelling accelerating agent. According to an embodiment of the disclosure, the active agent of the disclosure can be administered in the form of a nano-drug, liposome, micelle, or microparticle.

Pharmaceutical composition

An osteoinductive bone graft substitute including an osteoinductive calcium phosphate component retained within a collagen scaffold, wherein the collagen scaffold is formulated to maintain the osteoinductivity of the calcium phosphate component while also exhibiting the following characteristics (1) ability to absorb bone marrow and/or other physiologic liquids, (2) compression resistance; (3) moldability; (4) retaining the calcium phosphate component during and after manipulation of the collagen scaffold and (5) fibrous collagen matrix that retains but does not occlude the osteoinductive calcium phosphate component.

Osteoinductive bone graft substitute

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Taipei, Taiwan

Po-Hung Lai