Cephalon, Inc.

Ignyta, Inc.

Piyush R Patel

Anthony S Drager

Alpa B Parikh

Rachel Y LaBell

Roger P Bakale

Renee Caroline Roemmele

Martin J Jacobs

Robert E McKean

Peter D Brown

Jian Chen

Craig S Heacock

Bradley T McIntyre

David A Dickason

Vincent John Corvari

Joseph L Herman

Efraim Shek

Jeffry M Skell

Michael L Cappola

Bradley McIntyre

Denis Bricout

Helene Cambourieux

Nicole Frati

Dave Dickason

The present invention is directed to bendamustine esters and bendamustine amides and their use for the treatment of cancer.

Bendamustine derivatives and methods of using same

Compositions of modafinil and methods of treating neurologically related conditions with the administration of modafinil. Also compositions that include modafinil and one or more excipients such as diluents, disintegrants, binders and lubricants.

Pharmaceutical formulations of modafinil

Lyophilized cakes of proteasome inhibitors are described, as well as methods for their production and use.

Lyophilization cakes of proteasome inhibitors

Pharmaceutical compositions comprising modafinil in the form of particles of defined size and methods for preparing same. The particle size of modafinil can have a significant effect on the potency and safety profile of the drug.

Modafinil pharmaceutical compositions

Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.

Liquid formulations of bendamustine

Pharmaceutical compositions comprising modafinil. The pharmaceutical compositions can have a release profile which is different than that of traditional pharmaceutical compositions of modafinil.

Modafinil modified release pharmaceutical compositions

A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable suspension that provides greatly improved bioavailability of orally administered fused pyrrolocarbazole compounds.

Particle-forming compositions containing fused pyrrolocarbazoles

Particle-forming compositions of modafinil compounds, and aqueous compositions of particles, wherein the particles comprise a modafinil compound, are disclosed, along with methods of their preparation, and their use in the treatment of diseases.

Compositions comprising modafinil compounds

Mixtures of a modafinil compound with a cyclodextrin, methods for their use, and compositions thereof are disclosed, along with complexes comprising a modafinil compound and a cyclodextrin which are taste-masked and suitable for oral consumption in an aqueous solution.

Growing community of inventors

Wallingford, PA, United States of America

Piyush R Patel