Hoffmann-la Roche Inc.

Pius Anton Wehrli

Urs Oskar Hengartner

An explosive and propellant composition is obtained by admixing finely divided particles of ascorbic acid and a nitrate-containing oxidation agent, such as potassium nitrate. Admixing can be carried out in the dry state, at room temperature. The composition upon ignition gives off no sulfurous fumes, and leaves little or no carbon residue; and causes no corrosion with contacted metal surfaces.

Explosive and propellant composition and method

There are disclosed herein derivatives of bisfunctionalized compounds, wherein said compounds have been formed by the introduction of a nitro group and a hydroxyl group in the form of an ester into a conjugated diene molecule by treatment of said conjugated dienes with nitric acid in the presence of a carboxylic acid anhydride. The novel compounds produced by this process are useful as bactericides, fungicides and valuable organic synthesis intermediates.

Conjugated diene derivatives

A novel conjugated diene bisfunctionalization process wherein a nitro group and a hydroxyl group in the form of an ester are introduced into the conjugated diene molecule by treatment of conjugated dienes with nitric acid in the presence of an acid anhydride. The novel compounds produced by this process and transformation products thereof, are useful as bactericides and fungicides and valuable organic synthesis intermediates, A novel procedure for the production of nitriles and .gamma.-acetoxytiglic aldehyde is disclosed.

Novel cyano compounds

Preparation of 2,3,6-tri-lower alkyl phenols from the condensation product of an .alpha.,.beta.-unsaturated aldehyde with a dilower alkyl ketone.

Preparation of 2,3,6-tri-lower alkyl phenols

An improved process for the preparation of 6,6-alkylenedioxyalkan-2-ones starting from alkyl vinyl ketones and alkyl acetoacetates is disclosed. The 6,6-alkylenedioxyalkan-2-ones are useful as intermediates in the total synthesis of therapeutically valuable steroids.

Intermediate in the preparation of 6,6-alkylenedioxyalkan-2-ones

A process for producing 2-methyl-3-buten-2-ol by reacting isoprene with a hydrohalide and then with an aqueous base and then distilling the aqueous mixture in the presence of excess base to maintain the reaction mixture during distillation at a pH of at least 4.

Synthesis of 2-methyl-3-buten-2-ol

Process for the preparation of 6,6-alkylenedioxyalkan-2-ones

.gamma., .delta.-Unsaturated carbonyl compounds are prepared by reacting a tertiary allyl alcohol with an acetal or ketal of an aliphatic aldehyde or ketone in the presence of an acid catalyst system consisting of a strong acid and a weak acid.

Process for preparing .gamma., .delta.-unsaturated carbonyl compounds

2-Lower alkyl-cyclopentan-1,3-diones are prepared in high yield by cyclization of gamma-ketoesters in the presence of a colloidal suspension of an alkali metal primary lower alcoholate.

Growing community of inventors

North Caldwell, NJ, United States of America

Pius Anton Wehrli