Sterling Winthrop Inc.

Nanosystems L.l.c.

Piotr H Karpinski

Gregory L McIntire

Pranab Bagchi

Wolfgang H Gunther

Liladhar Murlidhar Waykole

Elaine Liversidge

Barbara Van Orman

Kenneth E Kellar

Michael Mutz

Christian Riegert

Ricardo Schneeberger

Lili Feng

Baoqing Gong

Lech Ciszewski

This invention describes the preparation of nanoparticulate pharmaceutical agent dispersion via a process that comprises the dissolution of the said pharmaceutical agent in an alkaline solution and then neutralizing the said solution with an acid in the presence of a suitable surface-modifying, surface-active agent to form a fine particle dispersion of the said pharmaceutical agent. This can be preferably followed by steps of diafiltration clean-up of the dispersion and then concentration of it to a desired level. This process of dispersion preparation leads to microcrystalline particles of Z-average diameters smaller than 400 nm as measured by photon correlation spectroscopy. Various modification of precipitation schemes are described, many of which are suitable for large-scale manufacture of these agent dispersions.

Microprecipitation of nanoparticulate pharmaceutical agents

This invention is directed to a magnetic resonance imaging composition for imaging of an organ rich in mitochondria comprising particles of a substantially insoluble manganese compound. In a preferred embodiment, the organ rich in mitochondria is the liver. In a further preferred embodiment, the particles are substantially nonmagnetic. In another preferred embodiment, the particles have a particle size of less than about 10 microns. In a still further preferred embodiment, the insoluble manganese compound is a manganese salt. The manganese compound is preferably selected from the group consisting of manganese phosphate, manganese carbonate and manganese 8-hydroxy quinolate. In another preferred embodiment, the composition of the present invention further comprises a surfactant. The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of a substantially insoluble manganese compound suspended or dispersed in a physiologically tolerable carrier and generating an NMR image of said mammal.

Water insoluble non-magnetic manganese particles as magnetic resonance

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Fairport, NY, United States of America

Piotr H Karpinski