Arch Development Corporation

The University of Chicago

Apicomplexan Therapeutics, LLC

Piotr Gornicki

Robert H Haselkorn

Stephen Joseph Kron

Rima McLeod

Craig Roberts

Ernest J Mui

Sergey A Kozmin

Fiona Roberts

Jennifer J Johnson

David Ferguson

Michael Kirisits

Russell Lyons

Jiayue Cui

Doug Mack

Benjamin Samuel

Olesya Ulanovskaya

Ellen Zuther

The present disclosure provides novel compounds of the formula (I): wherein R, R, R, R, R, R, and Rare as defined in the detailed description. Two preferred compounds of formulae (IX) and (X) are disclosed. Also disclosed are uses of the disclosed compounds, for example, in regulating glucose transport and in inhibiting acetyl coenzyme A carboxylase.

Scaffold-diversified pyrrolidinone derivatives and their use

This invention relates uses of chorismate synthase, a component components of plant-like metabolic pathways not including psbA or PPi phosphofructokinase and not generally operative in animals or encoded by the plastid DNA, in assays to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on chorismate synthase and its inhibitors.

Antimicrobial agents, diagnostic reagents, and vaccines based on unique Apicomplexan parasite components

The present invention provides isolated and purified polynucleotides that encode plant and cyanobacterial polypeptides that participate in the carboxylation of acetyl-CoA. Isolated cyanobacterial and plant polypeptides that catalyze acetyl-CoA carboxylation are also provided. Processes for altering acetyl-CoA carboxylation, increasing herbicide resistance of plants and identifying herbicide resistant variants of acetyl-CoA carboxylase are also provided.

Cyanobacterial and plant acetyl-CoA carboxylase

The present invention provides isolated and purified polynucleotides that encode plant polypeptides that participate in the carboxylation of acetyl-CoA. Also provided are methods for identifying such nucleic acid segments and polypeptides. Processes for altering acetyl-CoA carboxylation, increasing herbicide resistance of plants and identifying herbicide resistant variants of acetyl-CoA carboxylase are also provided.

Nucleic acid segments encoding wheat acetyl-CoA carboxylase

Acetyl-CoA carboxylase from wheat

Acetyl-CoA carboxylase compositions and methods of use

Nucleic acid compositions encoding acetyl-coa carboxylase and uses

Growing community of inventors

Chicago, IL, United States of America

Piotr Gornicki