Bio-technology General Corporation

Pinhas E Zeelon

Avigdor Levanon

Amos B Oppenheim

Marian Gorecki

Haim Aviv

Tikva Vogel

Menachem Zeevi

Analogs of hGH having the activity of naturally occurring hGH and a similar amino acid sequence varying from the sequence of natural hGh by the addition of one or more amino acids, e.g. methione or methionine-leucine, to the N-terminus of natural hGH have been produced, recovered and purified. Such analogs may be incorporated into pharmaceutical compositions and administered to a subject to increase the level of hGH in the subject. Analogs of hGH which comprise the amino acid sequence of natural hGH from the N-terminus of which one or more amino acids have been deleted, e.g. Met.sup.14 hGh, have been produced, recovered and purified. Such analogs may be incorporated into pharmaceutical compositions and administered to a subject to lower the level of hGH in the subject. A plasmid has been constructed which directs the expression of an analog of hGH having the amino acid sequence methionine-leucine added to the N-terminus of natural hGH. This plasmid has been introduced into Escherichia coli, the resulting Escherichia coli grown and the analog recovered and purified.

Growing community of inventors

Hashiva, Israel

Pinhas E Zeelon