Haisco Pharmaceuticals Pte. Ltd.

Pingming Tang

Chen Zhang

Yao Li

Pangke Yan

Fei Ye

Lei Chen

Bo Xu

Xin Liu

Zongjun Shi

Yajun Wang

Guobiao Zhang

Dengyu Zheng

Xiaobo Zhang

Wenjing Wang

Jia Ni

Jianmin Wang

Zhenggang Huang

Yuting Liao

Guozhi Zhu

Xiaogang Chen

Shoutao Wu

Disclosed is a nitrile derivative compound represented by formula (I), a stereoisomer, a deuterated product, a co-crystal, a solvate or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the description. The compound has dipeptidyl peptidase 1 inhibitory activity and can be used to prepare a drug for treating diseases including obstructive airway diseases, bronchiectasis, cystic fibrosis, asthma, emphysema, and chronic obstructive pulmonary diseases.

Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof

Substituted piperidines as BTK inhibitors, a preparation method thereof and a pharmaceutical application thereof. The substituted piperidines is a compound represented by a general formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, and the substituted piperidines is used to treat BTK-related diseases such as tumors or autoimmune system diseases.B-L-K&#x2003;&#x2003;formula (I)

Substituted piperidines as BTK inhibitors

Growing community of inventors

Chengdu, China

Pingming Tang