Nanjing Tech University

Nanjing University of Technology

Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory

Other

Zhe Jiang Medicine Co., Ltd

Nanjing Universty of Technology

Pingkai Ouyang

Kai Guo

Zheng Fang

Ning Zhu

Ke Wang

Wei He

Junjie Tao

Kai Zhang

He Huang

Hanjie Ying

Shiqing Pi

Chunlei Lv

Jianhui Chen

Dingqiang Lu

Chengkou Liu

Zhenjiang Li

Bin Wu

Sen Zhang

Yong Chen

Dong Liu

Xin Hu

Bin Yu

Qingguo Liu

Ming Lei

Huanqing Niu

Bingfang He

Xueming Wu

Jianlin Chu

Li Wan

Jiangkai Qiu

Jingjing Meng

Jindian Duan

Qi Yu

Ming Li

Di Zhang

Wei Zhuang

Chenjie Zhu

Yuming Zhang

Hong Xu

Tao Shen

Kequan Chen

Rui Wang

Sha Li

Chuanhong Qiu

Shiyu Guo

Xinjian Xu

Jiannong Shen

Man Yang

Jingyi Wang

Chaorong Dai

Chengfeng Li

Minghui Tang

Houliang Dai

Jinfeng Liang

Xiaohai Feng

Bo Chi

Dong Ji

Xingyuan Cao

Xiwei Peng

Shishi Wu

Yuhan Yang

Jintang Wang

Jianning Guan

Lijin Zhou

Ping Song

Chang Guo

Yanqin Wang

Suli Kan

Shichuan Sheng

A method of a polyurethane foam includes the following steps of: (1) simultaneously pumping a mixed solution prepared from hydrogen peroxide, an organic acid, a catalyst and a stabilizer and a vegetable oil into a first microstructured reactor of a micro-channel modular reaction device for reacting to obtain a reaction solution containing epoxidized vegetable oil; (2) simultaneously pumping the reaction solution containing the epoxidized vegetable oil obtained from the step (1) and a compound of formula III into a second microstructured reactor of the micro-channel modular reaction device for reaction to obtain a vegetable oil polyol; and (3) reacting the vegetable oil polyol prepared from the step (2) with a foam stabilizer, a cyclohexylamine, an isocyanate and a foaming agent cyclopentane for foaming so as to prepare a rigid polyurethane foam.

Preparation method of polyurethane foam

A preparation method of a flexible polyurethane foam includes the following steps of: (1) subjecting an epoxidized vegetable oil, a benzoylformic acid, a basic catalyst, and an inert solvent to a ring-opening reaction in a first microchannel reactor of a microchannel reaction device to obtain a vegetable oil polyol; (2) subjecting the vegetable oil polyol obtained in the step (1), a propylene oxide and an inert solvent to an addition polymerization reaction in a second microchannel reactor of the microchannel reaction device to obtain a vegetable oil polyol for flexible polyurethane foam; and (3) using the vegetable oil polyol for flexible polyurethane foam obtained in the step (2) as the unique polyol, and subjecting the same and an isocyanate polyol to a foaming reaction to obtain the flexible polyurethane foam.

Preparation method of flexible polyurethane foam

The invention belongs to the field of rubber tire processing, and particularly discloses an application of a lignin in preparing a radial tire, wherein the lignin is capable of completely or partially replacing resorcinol, and meanwhile, the lignin is also capable of completely or partially replacing an anti-aging agent. Compared with the prior art, the resorcinol is replaced or partially replaced by a biomass-derived lignin or a modified lignin in the invention, so that requirements of cost reduction, environmental protection and no toxicity are satisfied. Especially, the lignin modified by demethylation according to the invention is capable of effectively enhancing various properties of rubber.

Application of lignin in preparing radial tire

A method for preparing a polyol comprises the following steps of: (1) dissolving 2,3 -epoxybutane and an acid catalyst in an inert solvent to obtain a solution A; dissolving triethylene glycol in an inert solvent to obtain a solution B; and dissolving epoxy vegetable oil in an inert solvent to obtain a solution C; (2) respectively and simultaneously pumping the solutions A and B into a first micromixer for mixing; (3) pumping the solution C and an effluent of the first microreactor into a second micromixer for mixing while carrying out step (2); and (4) dissolving the vegetable oil polyol in an inert solvent to obtain a solution D; dissolving epoxypropane and an alkaline catalyst in an inert solvent to obtain a solution E; and pumping the solution D and the solution E into a tank reactor for reaction, thereby obtaining the polyol.

Preparation method for polyol and application of polyol in making polyurethane

It discloses a polyether polyols for preparing flexible polyurethane foam, and a preparation method and application thereof. The method comprises the following steps: (1) carrying out a reaction on phosphorus oxychloride, epichlorohydrin, a first acidic catalyst and an inert solvent in a first microchannel reactor to obtain a chloroalkoxy phosphorus compound; (2) carrying out a reaction on the chloroalkoxy phosphorus compound, glycidol, a second acidic catalyst and an inert solvent in a second microchannel reactor to obtain a hydroxy compound; (3) carrying out a ring-opening reaction on the hydroxy compound, epoxy vegetable oil, a basic catalyst and an inert solvent in a third microchannel reactor to obtain a vegetable oil polyol; and (4) carrying out an addition polymerization reaction on the vegetable oil polyol, propylene oxide and an inert solvent in a fourth microchannel reactor to obtain the polyether polyols for preparing flexible polyurethane foam.

Polyols for preparing flexible polyurethane foam, and preparation method and application thereof

The invention discloses a recombinantfor producing lysine by biofilm continuous fermentation and a construction method thereof, wherein the recombinantis constructed by overexpressing a protease gene FtsH in a; and the construction method comprises the following steps of: (1) performing PCR on a genome of the, and amplifying the FtsH gene to obtain an amplified FtsH gene segment; (2) cloning the FtsH gene segment to an overexpression plasmid to obtain a recombinant plasmid; and (3) introducing the recombinant plasmid into the, and screening to obtain the recombinant. The invention has the beneficial effects that thefor overexpressing the protease FtsH is constructed in the invention, and a film-forming ability of theis enhanced, such that a yield of continuous immobilized fermentation of theis increased by 38.2% than that of free fermentation of an original bacterium, and a fermentation cycle is shortened by 26.4%.

Recombinant corynebacterium glutamicum for producing lysine by biofilm continuous fermentation and construction method thereof

The invention discloses a method for producing lysine by utilizing adsorption and immobilized fermentation of a recombinant, wherein the recombinantis constructed by simultaneously overexpressing an adenosine triphosphate ATPase while knocking out an extracellular nuclease ExeR in a. The recombinantcan effectively improve eDNA secretion of theand reduce eDNA degradation of the, so that thecan be more easily adsorbed on a surface of a solid carrier for immobilized fermentation, such that a yield of continuous immobilized fermentation of theis increased by 49.67% than that of free fermentation of an original bacterium, and a fermentation cycle is shortened by 29.17%.

Method for producing lysine by utilizing adsorption and immobilized fermentation of recombinant corynebacterium glutamicum

A preparation method of vegetable oil polyol, which is obtains by carrying out allylic oxidation treatment of vegetable oil, increasing the content of hydroxyl group in the product and then one step reaction between epoxidation and ring-opening. At the same time, the present invention also discloses novel vegetable oil polyol made by the preparation method and the application of the vegetable oil polyol in preparation of polyurethane foam material. Compared with the prior art, the method has the advantages of simple operation, low energy consumption and low side reaction occurrence rate.

Vegetable oil polyol and the preparation method and the application thereof

The present invention discloses a &#x3b5;-polylysine hydrogel and the preparation method and application of the as-described &#x3b5;-polylysine hydrogel. The polylysine hydrogel is non-toxic to a recipient, and has biodegradability and biocompatibility. The wound tissue healing material prepared by the present invention can be used in wound tissue adhesion in an efficient, stable, safe manner.

E-polylysine hydrogel and preparation method and application thereof

Provided in the present invention is a preparation method for a phosphonic salt, comprising the step of: reacting 3,7,11-trimethyldodec-1,4,6,10-tetraene-3-ol with triarylphosphine and an acid in an alcohol solvent at 50-100&#xb0; C. to form the phosphonic salt, wherein the acid is a sulfamic acid or methanesulfonic acid, and the alcohol solvent is a straight chain monohydric alcohol containing 1-5 carbon atoms. The method is performed in nearly neutral conditions, greatly reducing the generation of impurities and greatly obtaining phosphonic salt with an increased E content. The yield of lycopene obtained by using the phosphonic salt as a raw material is high.

Preparation method of 3,7,11-trimethyldodec-2,4,6,10-tetraene-1-yl-phosphonic salt

A method for preparing caprolactam by using a microreactor under Lewis acid catalysis, wherein a hydroxyl group in a cyclohexanone oxime is activated to obtain a cyclohexanone oxime sulfonates intermediate, then rearranged under Lewis acid catalysis to prepare the caprolactam. The method of this invention has a simple process and a high operation safety and selectivity, the reaction condition is mild, an efficient reaction can take place even at room temperature, the reaction time is short, the conversion of the cyclohexanone oxime can reach 100% within a short time, the selectivity of the caprolactam can reach 99%, the energy consumption is greatly reduced in the premise of maintaining a high yield, and the production cost is reduced, being an efficient and green and environmentally friendly method of for synthesizing the caprolactam.

Method for preparing caprolactam by using a microreactor under lewis acid catalysis

A method for preparing a high-quality epoxidized fatty acid ester with a micro-reaction device, including: respectively pumping an aqueous hydrogen peroxide solution and a carboxylic acid at the same time into a first micro-mixer; after the reaction in the first micro-reactor, respectively pumping the output material and an unsaturated fatty acid ester into a second micro-mixer; completely mixing them and then introducing the mixture into a second micro-reactor; and after a complete reaction, water-rinsing the organic phase part of the resultant reaction liquid and drying the same to obtain the epoxidized fatty acid ester.

Method for preparing high-quality epoxidized fatty acid ester with micro-reaction device

Provided in the present invention is a method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde. The synthesis method comprises the following steps: (1) adding acetaldehyde diethyl acetal and ethyl-(1-propenyl)-ether under the effect of a catalyst to produce 1,1,3-triethoxy-2-methyl-butane; (2) pyrolysis synthesizing 1,1,3-triethoxy-2-methyl-butane under the catalytic effects of isoquinoline and p-Toluenesulfonic acid to produce 1-methoxy-2-methyl-1,3-butadiene; (3) dissolving 1-methoxy-2-methyl-1,3-butadiene in anhydrous ethanol solvent for synthesis with a phase transfer catalyst, cetyl-trimethyl ammonium bromide, and a chlorinating agent, trichloroisocyanuric acid, to generate 4,4-diethoxy-3-methyl-1-chloro-butene; (4) combining 4,4-diethoxy-3-methyl-1-chloro-butene with a triphenylphosphine salt to produce a phosphonium salt; and (5) condensing the phosphonium salt under the effects of hydrogen peroxide in conjunction with sodium carbonate solution to generate 1,1,8,8-tetramethyl-2,7-dimethyl-2,4,6-octatriene; then hydrolyzing under acidic conditions to synthesize 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde. The present invention has a simple process route, is easy to operate, and has mild conditions, great yield, and great industrial value.

Method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde

This disclosure provides methods of controlled polymerization of cyclic compounds catalyzed by carbene derivatives having a general formula as shown below, and to obtain a biodegradable polymeric material having a large molecular weight, a narrow dispersity, and no metallic impurity. 

Ring-opening polymerization of cyclic compounds catalyzed by carbene derivatives

This disclosure provides a method of making polylactic acid using carbon dioxide adducts of carbenes, wherein the adducts of carbenes have a structure represented by formula (I) as follows: 

Method of making polylactic acid using carbene derivatives as the catalyst

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Nanjing, China

Pingkai Ouyang