Industrial Technology Research Institute

Everfront Biotech Inc.

Ejia Biotechnology Co., Ltd.

Ping-Shan Lai

Shinn-Zong Lin

Horng-Jyh Harn

Shiaw-Min Hwang

Hong-Lin Su

Chia-Yu Chang

Huai-En Lu

Jinn-Jong Wong

Mu-Jen Young

Jenn-Line Sheu

Te-Lung Chang

Chen-Ji Kao

Chia-yu Chang

The present invention discloses use of butylidenephthalide (Bdph), a method of using the same, and a method for preparing a pharmaceutical composition containing the same. Because Bdph has the capability of promoting the hair growth and reducing the &#x3b2;-amyloid protein (A&#x3b2;) level in nerve cells, the efficacy of improving the health and appearance of a subject can be achieved by administrating an effective amount of Bdph to the subject. Specifically, the Bdph has the efficacy of preventing or treating neurodegenerative diseases such as Alzheimer's disease caused by excessive build up of A&#x3b2; in the cells, and as an active ingredient in a topical composition, the Bdph is effective in promoting the hair growth at the site where the Bdph is administered. Furthermore, the method for preparing a pharmaceutical composition containing Bdph comprises preparing the pharmaceutical composition through an organic synthesis reaction, wherein the Bdph is coated with a polymeric material such as F127 by covalent bonding of the polymeric material with the Bdph, thereby achieving the effect of reducing the cytotoxicity of the pharmaceutical composition for an organism.

Use of butylidenephthalide (Bdph), method of using the same, and method for preparing pharmaceutical composition containing the same

A micro-channel reaction apparatus includes a first mixing device and a first jetting device. The first mixing device includes a first inflow channel and a second inflow channel respectively used to direct a first fluid and a second fluid into the micro-channel reaction apparatus. The first jetting device includes a first tapering portion and a first flared portion, wherein one end of the first tapering portion is connected to the first inflow channel and the second inflow channel; another end of the first tapering portion is connected to the first flared portion; and the first tapering portion has a contract ratio of inner diameter ranging from 0.1 to 0.75.

Micro-channel reaction apparatus

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Taichung, Taiwan

Ping-Shan Lai