Shenyang Pharmaceutical University

Chinese Academy of Sciences

Shenyang Pharmaceutical University (benxi) Pharmaceutical Science and Technology Co., Ltd.

Ping Gong

Yanfang Zhao

Yajing Liu

Xin Zhai

Lili Zhang

Sai Li

Dongpo Li

Zhijie Wu

Wufu Zhu

Mingze Qin

An application of farnesene in preparing a plant-derived urease inhibitor is provided. The compound can effectively inhibit activities ofurease and soil urease, and has an effect that is equivalent to that of commercial urease inhibitor acetohydroxamic acid. The urease inhibitor in the present disclosure, derived from plants, has 'pollution-free' characteristics of natural products, high biological safety, simple and stable chemical structure and remarkable urease inhibition effect, can solve the problems of conventional chemically-synthesized urease inhibitor such as high toxicity, easy degradation and poor stability, also provides a new concept for creating a biological ecological technology for efficiently inhibiting the rapid hydrolysis of urea in farmland and increasing the utilization rate of urea nitrogen fertilizer, and has good application value and development prospect.

Application of farnesene in preparing plant-derived urease inhibitor

The invention relates to a series of quinoline derivatives of general formula I, pharmaceutically acceptable salts, hydrates, solvates or prodrugs. Thereof M, R, R, X, Y and n are defined as claims. And the compounds of general formula I show potent inhibitory activity against c-Met kinase. The present invention further relates to the uses of the compounds, pharmaceutically acceptable salts and hydrates for the preparation of medicaments for the treatment and/or prevention of diseases caused by abnormal expression of c-Met kinase, especially for treatment and/or prevention of cancer. 

Quinoline derivatives and their applications

The present invention relates to a series of quinoline and cinnoline derivatives of general formula I, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof. And the compounds of general formula I show potent inhibitory activity gainst c-Met kinase. The present invention further relates to the uses of the compounds, pharmaceutically acceptable salts and hydrates for the preparation of medicaments for the treatment and/or prevention of diseases caused by abnormal expression of c-Met kinase, especially for treatment and/or prevention of cancer. 

Quinoline and cinnoline derivatives and their applications

The present invention relates to 5-hydroxy-indole-3-carboxylate derivatives of formula I, or racemic mixture or optical isomers or pharmaceutically acceptable salts and/or hydrates thereof, wherein: substituents R, R, Z, X and Y are as defined in the description. The compounds of formula I can be useful for preparation of medicament for treatment and/or prophylaxis of virus infections, especially for preparation of medicament for anti-HBV (Hepatitis B virus) and anti-HIV (Human immunodeficiency virus).

5-hydroxyindole-3-carboxylate derivatives and uses thereof

Growing community of inventors

Shenyang, China

Ping Gong