Industrial Technology Research Institute

Aiptek International Gmbh

National Health Research Institutes

Shin Kong Wu Ho Su Memorial Hospital

Bio Preventive Medicine Corp.

Ping-Fu Cheng

Tzu-Ling Tseng

Wei-Ya Lin

Hung-Yi Li

Yen-Peng Li

Mary Ya-Ping Yeh

Yi-Ting Chen

Tsai-Wei Hsu

Jin-Shuen Chen

Yuh-Feng Ling

Maggie Lu

Yi-Ju Ko

Yi-Chen Liu

Chun-Min Liu

Angelina Huai-Lo Lee

Hong-Zen Yeh

Li-Wen Chang

Pei-Shin Jiang

On Lee

Tseng-Huang Liu

Jenn-Tsang Hwang

Po-Yen Lin

Shih-Feng Tsai

Chia-Yu Fan

Chi-Y Hung

Ya-Ling Chiu

Shih-Ta Chen

Jheng-Sian Li

Kang-Li Wang

Hou-Chang Chiu

Pei-Hsiu Liao

Chen-Loon Chang

Lien-Chen Lin

May-Hua Chang

Yuh-Feng Lin

Giien-Shuen Chen

A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.

Nucleic acid-drug complex and use thereof

A linker-drug represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), C is a conjugator, L is a linker unit, D is a toxin unit, and n is an integer ranging from 1 to 4. The structure of the conjugator is represented by formula (II). In formula (II), X is a leaving group, each of Rand Ris independently a single bond or &#x2014;NH&#x2014;, and Z is substituted aryl, heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) employing the above linker-drug is also provided. 

Linker-drug and antibody-drug conjugate (ADC) employing the same

An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided.A-(L-D)&#x2003;&#x2003;(I)

Antibody-drug conjugate (ADC) and method for forming the same

Described is a method of detecting a protein fragment in a urine sample and a serum sample. The protein fragment is a urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, or serum osteopontin fragment. The urine sample and the serum sample are obtained from the same individual.

Method of detecting a urine protein fragment and a serum protein fragment

Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and &#x3b2;-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing and staging liver fibrosis.

Biomarkers useful in liver fibrosis diagnosis

Identification of urokinase-type plasminogen, matrix metalloproteinase 9, and &#x3b2;-2-microglobulin as novel biomarkers associated with liver fibrosis and uses thereof in diagnosing liver fibrosis.

Disclosed is use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.

Urine and serum biomarkers associated with diabetic nephropathy

A digital photo frame with photographing function includes a digital frame, a lens module, a bracket, and a copy stand. The digital frame may further include a display module, a frame, a memory module, a control module, an input module, a power supply module, and a sense module. The display module is framed within the frame, and the lens module is disposed at a predetermined location on the frame. A paper photo can be disposed on the copy stand that is pivotally connected to the bracket. The input module can input a control signal to operate and control the lens module to copy photograph the paper photo into a digital photo and store the digital photo in the memory module and further display the digital photo on the display module.

Digital photo frame with photographing function

The present invention relates to methods of diagnosing myasthenia gravis in a subject, by determining an amount of at least one autoantibody that specifically binds one or more autoantigens selected from heat-shock protein 60 (hsp60), heat-shock protein 90, alpha isoform (hsp90&#x3b1;), and heat-shock protein 90, beta isoform (hsp90&#x3b2;). The invention also provides diagnostic kits for identifying a subject having myasthenia gravis.

Method of diagnosing myasthenia gravis and kits therefor

Network camera

Growing community of inventors

Xizhou, Taiwan

Ping-Fu Cheng