Yangtze River Pharmaceutical Group Co., Ltd.

Shanghai Haiyan Pharmaceutical Technology Co., Ltd.

Ping Bu

Liang Zhang

Jiong Lan

Fusheng Zhou

Yunzhou Jin

Xiang Chen

Qi Yang He

Chong Wen

Xiangyu He

Yingtao Liu

Ming Weng

Pengfei Cheng

Leitao Zhang

The present invention relates to a sulfuryl-substituted benzoheterocyclic derivative, a preparation method and medical use thereof. Particularly, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, and a preparation method and application thereof. The definition of each group in the formula can be found in the specification and the claims. 

Sulfuryl-substituted benzoheterocyclic derivative, preparation method and medical use thereof

Azabicyclo derivatives, a preparation process, and medical use thereof are provided. In particular, azabicyclo derivatives of formula (I), pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs thereof are described. The azabicyclo derivatives of formula (I) are useful as Epidermal Growth Factor Receptor (EGFR) inhibitors. The definitions of the variable R groups in the azabicyclo derivatives of formula (I) are described in the specification. 

Azabicyclo derivatives, process for preparation thereof and medical use thereof

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Shanghai, China

Ping Bu