Medarex Inc.

Pina M Cardarelli

Sanjeev Gangwar

Christopher Robert Bebbington

Chin Pan

Lesley B Pickford

Matthew H Nieder

The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing the prodrug are also disclosed.

CD10-activated prodrug compounds

The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed.

Growing community of inventors

San Carlos, CA, United States of America

Pina M Cardarelli