California Institute of Technology

University of California

University of Southern California

Pin Wang

David Baltimore

Lili Yang

David A Tirrell

Yi Tang

Antoni Ribas

Inchan Kwon

James Economou

Soojin Son

Stephen L Mayo

Xiaolu Han

Paul Bryson

Lilli Yang

Deepshikha Datta

Isaac Carrico

Yu Jeong Kim

Natnaree Siriwon

The invention is directed to a masked chimeric antigen receptor, comprising: (a) a masking peptide; (b) one or more antigen-specific targeting domains; (c) an extracellular spacer domain; (d) a transmembrane domain; (e) at least one co-stimulatory domain; and (f) an intracellular signaling domain. The mCARs are activated upon cleavage of the masking peptide.

Masking chimeric antigen receptor T cells for tumor-specific activation

Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

Packaging cell for making a pseudotyped lentivirus

Methods of delivering a pseudotyped lentivirus

Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

Method of targeting gene delivery using viral vectors

Recombinant retrovirus pseudotyped with E2 alphavirus glycoprotein

Method of stimulating an immune response using a pseudotyped lentivirus

The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.

Site-specific incorporation of amino acids into molecules

Recombinant retrovirus pseudotyped with a E2 alphavirus glycoprotein

Method of targeted gene delivery using viral vectors

Packaging cells for producing retrovirus pseudotyped with an E2 alphavirus glycoprotein

T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma.

MART-1 T cell receptors

Recombiant lentivirus comprising an E2 alphavirus glycoprotein that binds to DC-SIGN

Targeted gene delivery for dendritic cell vaccination

Targeted gene delivery to dendritic cells

Growing community of inventors

Arcadia, CA, United States of America

Pin Wang