Jiangsu Alphamab Biopharmaceuticals Co., Ltd.

Suzhou Alphamab Co., Ltd.

3d Medicines Co., Ltd.

Pilin Wang

Ting Xu

Xiaoxiao Wang

Yuhao Jin

Kangping Guo

Dong Yang

Qian Li

Ting Chen

Yanrong Dong

Disclosed are a method for treating a tumor using a CTLA4-binding protein and a use thereof, wherein the CTLA4-binding protein specifically binds to CTLA4 and does not compete with a ligand of CTLA4 for binding to CTLA4. The CTLA4-binding protein described in the present application can effectively inhibit tumor growth.

Method for treating tumor using anti-CTLA4 single-domain antibodies

The present disclosure provides a dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4.

Dimers and use thereof

The present invention relates to the field of medical biology and discloses a single domain antibody and derivative proteins thereof against programmed death ligand (PDL1). In particular, the present invention discloses a programmed death ligand 1 (PDL1) binding molecule and the use thereof, especially the use for treating and/or preventing or diagnosing PDL1 relevant diseases such as tumor.

Single domain antibody and derivative proteins thereof against programmed death-ligand (PDL1)

Growing community of inventors

Jiangsu, China

Pilin Wang