Korea Advanced Institute of Science and Technology

Institute for Basic Science

Ivim Technology, Inc.

Pilhan Kim

Gou Young Koh

Jaeryung Kim

Wangyuhl Oh

Jeomil Bae

Mi Jeong Kim

Jang Ryul Park

Jin-Sung Park

Su Jin Seo

Yoonha Hwang

Eunjoo Song

The present invention relates to a fixation and body temperature maintaining apparatus for fixing a small animal in order to generate a high-resolution micro image of a predetermined tissue of the small animal within a biomicroscope with an object lens, which includes: a plate heater with a heat wire installed therein, on which the small animal is enabled to be directly placed; a glass heater holder fixed to a hole of the plate heater; and a glass heater fixed to the glass heater holder, and located above the tissue of the small animal and maintaining flatness of the tissue, and increasing a temperature of the tissue itself, in which a cover glass serving to adjust a refractive index of the object lens and a heat wire heater are integrally formed. In an embodiment of the present invention, a body temperature of a live small animal which is an object to be observed with a biomicroscope is maintained to be constant.

Apparatus for homeothermic manipulation of live animal for microscopic imaging of internal tissue

The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.

Anti-angiopoietin-2 antibodies that induce Tie2 activation

Growing community of inventors

Daejeon, South Korea

Pilhan Kim