Scinopharm Taiwan, Ltd.

Piin-Jye Harn

Shu-Ping Chen

Tsung-Cheng Hu

Chia-Lin Charlene Shieh

A crystalline polymorph of 7-ethyl-10-hydroxycamptothecin exhibiting an X-ray diffraction pattern having peaks at 10.9&#xb1;0.2, 13.2&#xb1;0.2, 23.9&#xb1;0.2, and 26.1&#xb1;0.2 2-theta degree.

Crystalline polymorph of 7-ethyl-10-hydroxycamptothecin

Novel crystalline forms of topotecan hydrochloride and processes of making the same are disclosed.

Crystalline forms of topotecan hydrochloride and processes for making the same

A process of making topotecan or a pharmaceutically acceptable salt thereof comprising reacting an iminium salt with 10-hydroxy-camptothecin.

Process for making topotecan

The present invention provides for novel crystalline forms of irinotecan hydrochloride and processes for their preparation, pharmaceutical compositions containing the novel forms and methods for treating metastatic carcinoma of the colon or rectum using same.

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Tainan, Taiwan

Piin-Jye Harn