Institute for Cancer Research

Institut Curie

Institut De Genetique Et De Biologie Moleculaire Et Cellulaire

Institute for Cancer Research D/b/a the Research Institute of Fox Chase Cancer Center

Institut De Genetique Et De Biologie Moleculaire Et Cellularire

Pietro Mancuso

Vikram Bhattacharjee

Alfonso Bellacosa

Rossella Tricarico

Lionel Larue

Tim Yen

Timothy J Yen

Neil Beeharry

Mitchell Smith

Irwin Davidson

The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.

Inhibition of thymine DNA glycosylase in the treatment of cancer

The invention provides methods for enhancing the cytotoxicity of DNA damage in cancer cells that express thymine DNA glycosylase, and treating tumors accordingly. The methods comprise inhibiting the expression or biologic activity of thymine DNA glycosylase, and inducing DNA damage in the cancer cells. DNA damage may be induced by administration of bendamustine or gemcitabine to the cancer cells.

Combination of DNA repair inhibition with bendamustine or gemcitabine in the treatment of cancer

Growing community of inventors

Philadelphia, PA, United States of America

Pietro Mancuso