Bracco Imaging S.p.a.

Industrie Chimiche Caffaro S.p.a.

Serichim S.r.l.

Pietro Delogu

Carlo Felice Viscardi

Alfonso Nardelli

Stefano Sguassero

Roberta Fretta

Fernanda Di Giorgio

Livius Cotarca

Pier Lucio Anelli

Giovanni Battista Giovenzana

Lorenza Fugazza

Walter Baratta

Federica Buonsanti

Silvia Ceragioli

Stefano Alini

Bruno Danieli

Armando Mortillaro

Rosario Velardi

Fabrizio Goffredi

Sabrina De Rosa

Rosario Figliolia

Sylvia Ceragiolli

Mariangela Boccalon

Ilaria Adamo

The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.

Method for the preparation of (S)-2-acetyloxypropionic acid and derivatives thereof

The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.

Continuous process for the preparation of (S)-2-acetyloxypropionic acid chloride

The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.

Process for the preparation of a iodinating agent

A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.

Process for preparing cyclohexanediacetic acid monoamide

Method for preparing coumarin and derivatives thereof

Growing community of inventors

Trieste, Italy

Pietro Delogu