Clariant Lsm Italia S.p.a.

Clariant Life Science Molecules (italia) S.p.a.

Clariant Life Science Molecules (italy) S.p.a.

Cooperativa Farmaceutica Soc. Coop. R.l.

Pietro Bellani

Marco Frigerio

Aldo Banfi

Patrizia Castoldi

Luigi Valcarenghi

A new method is described here for the synthesis of (S)-N-tert-butyl-1,2,3,4-tetrahydroiso-quinoline-3-carboxamide comprising the following steps: The method in question makes it possible to obtain (S)-N-tert-butyl-1,2,3,4-tetrahydroiso-quinoline-3-carboxamide with high yields and purity without using toxic and hazardous reagents.

Method of preparation of (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide

A process is described which permits the preparation of Ritonavir with only five intermediate stages using the same starting materials as those used in the process described in WO 94/14436; the process described here is also particularly satisfactory from the point of view of environmental impact because nearly all of the carbon atoms used are subsequently incorporated in the final molecule. Finally, the improvement afforded by this novel process is linked with the fact that an inexpensive reagent, such as bis-trichloromethyl carbonate (BTC), is used in two of the five stages.

Process for the synthesis of ritonavir

Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide

A pharmaceutical composition comprising as the active principle the piperazine salt of (S) 6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid in highly micronized form, suited carriers in which the active principle is scarcely soluble, surfactants, preserving agents and an hydrophilic, pH-independent, matrix consisting of alkyl derivatives of cellulose and/or polyvinylalcohol. The sustained release of the antiinflammatory compositions allows the treatment of affections by means of a single daily administration of the same.

Antiinflammatory pharmaceutical composition endowed with sustained

Growing community of inventors

Milan, Italy

Pietro Bellani