Universiteit Gent

Bioactor Bv

Microbial Research Management Health Nv

Prodigest Bvba

Bioactor Bvba

Pieter Van Den Abbeele

Sam Possemiers

Massimo Marzorati

Tom Van De Wiele

Willy Verstraete

Selin Bolca

Barbara Vanhoecke

Cindy Duysburgh

Tim Windels

Louis-Philippe Mascart

Patrice D Cani

Nathalie Maria Nelly Delzenne

Audrey Martine Neyrinck

Hans Van Der Saag

Peter Frank Ekhart

Iris Pinheiro

Nathalle Maria Delzenne

Cani Patrice D D

Gastrointestinal tract simulation system and compartment therefor. The compartment comprising a vessel having an open top surrounded by a peripheral edge portion and an air-tight lid system configured to be placed onto the peripheral edge portion. The lid system comprises a body with a plurality of passageways extending through the body and providing access to the interior of the vessel, the plurality of passageways comprising passageways for fluid transfer tubes and passageways for mounting at least one sensor component. The lid system is provided with releasable sealing elements for sealing the plurality of passageways and at least one pressing element which is common to at least a number of the sealing elements and configured for applying pressure to each of the respective sealing elements to effect the sealing of the respective passageways.

Gastrointestinal tract simulation system, compartments therefor, and method

The present invention relates to the use of carotenoids, in particular a microbial carotenoid compound of formula I, such as methyl-glycosyl-apo-8'-lycopenoate or glycosyl-apo-8&#x2032;-lycopene, for restoring and/or maintaining a health-beneficial gut microbial composition in a subject. The invention further provides the use of said compound in the treatment of disorders associated with a disturbed intestinal barrier integrity, such as for example irritable bowel syndrome. Further, a compound or composition comprising a microbial carotenoid compound is disclosed for use in the prevention and/or treatment of disorders associated with disturbed intestinal barrier integrity.

Microbial carotenoids affecting gut microbial composition

A method is provided for co-culturing viable cells and microorganisms for at least 48 hours in which an adhesion module is provided including a basal compartment and a luminal compartment separated by a semi-permeable membrane, and a continuous or semi-continuous flow of fresh medium is applied to the basal compartment.

Technology and method to study microbial growth and adhesion to host-related surfaces and the host-microbiota interaction

The present invention is directed to a particular arabinoxylan ('AX') preparation and the finding that this preparation has a beneficial effect on the organization of the intestinal microbial community in the lumen and in particular at the site of the gut mucosa, where it modulates the barrier function of the intestinal surface, primarily by modulating the mucosa-associated microbial community towards a relative increase of health beneficial bacteria, such as bifidobacteria and lactobacilli. It is accordingly a first aspect of the present invention to provide said arabinoxylan preparation characterized in comprising isolated water-soluble arabinoxylans and the use thereof to improve functioning (e.g. barrier function) of the intestinal epithelium. Thus, in a further aspect the present invention provides compositions, both pharmaceutical and nutritional compositions, comprising said arabinoxylan preparations; in particular pharmaceuticals, medical foods, food supplements or food compositions, such as infant formula products, dairy products, bakery products or pastry products. The compositions optionally comprise probiotics such asor

Arabinoxylans for modulating the barrier function of the intestinal surface

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Lokeren, Belgium

Pieter Van Den Abbeele