Koninklijke Philips Corporation N.v.

Asml Netherlands B.v.

Biocartis, Nv

Hemics B.v.

Philips Lighting Holding B.v.

Demcon Hemics B.v.

Pieter Klaas De Bokx

Hugo Hubertus Knobel

Ruud Johannes Theodorus Soers

Tjarko Adriaan Rudolf Van Empel

Anke Pierik

Wouter Harry Jacinth Rensen

Ronald Johannes Hultermans

Martijn Van Zelst

Rene Bakker

Adrianus Cornelius Antonius Jonkers

Henk Van Damme

A system and method to determine a disease activity as a single value by way of optical measurements in order to facilitate an analysis of a current disease status and a future course of disease, thus assisting a doctor's diagnosis or decision on a therapy. A blood perfusion is varied in an area of interest, the area of interest is irradiated with light of at least two wavelengths, an intensity of light reflected and/or transmitted by the area of interest is detected, features are derived from detected intensity curves of at least two predetermined wavelengths under at least two different perfusion conditions, and the disease activity is determined using these features.

Device and method for determining a disease activity

A pre-concentration device is provided for a gas analysis system () for collecting molecular contamination in a vacuum environment (). The pre-concentration device () comprises a hollow element () having an entrance opening () for receiving molecules from the vacuum environment () in a collection phase, a gas outlet for transferring collected molecules to a vacuum compatible detector or second preconcentration device in a transfer phase. The device has an inner wall for adsorbing molecules in the collection phase and desorbing molecules in the transfer phase. The device has a filler element () that is movable from a first position outside the hollow element in the collection phase to a second position inside the hollow element in the transfer phase which second position leaves open a transfer channel to the gas outlet along the inner wall. Advantageously, the device enables transferring of the organic or inorganic contaminants collected in the device under vacuum conditions, and requires a minimal amount of ultra pure gas for the transport of the contaminants to a detector or further a concentration device, which lowers the lower limit of detection.

Analysis of molecular contamination in vacuum environments

The present invention relates to a method for producing a storable dry composition of biomolecule. First a composition is dispensed on a surface. The composition comprises at least a biomolecule, at least a liquid volatile component, at least a polysaccharide being designed for forming together with the at least a biomolecule and a part of the at least a liquid volatile component a matrix displaying a glass transition temperature Tg. Secondly, at least a part of the liquid volatile component is evaporated by adjusting the temperature of said composition to allow the formation of the matrix. Said evaporation step is initiated at an initial temperature T, and finished up at a final temperature T, said final temperature Tbeing above said initial temperature T

Biomolecule drying process for long-term storage

A lithographic projection apparatus includes a radiation system constructed and arranged to supply a projection beam of radiation, a support structure constructed and arranged to support a patterning structure, the patterning structure constructed and arranged to pattern the projection beam according to a desired pattern, a substrate support constructed and arranged to support a substrate, and a projection system constructed and arranged to project the patterned beam onto a target portion of the substrate. The apparatus further includes a gas flushing system comprising radial gas flow outlets, said gas flushing system being constructed and arranged to generate a radial gas flow through said radial gas flow outlets in an intermediate space defined between said gas flushing system and said substrate, wherein the radial gas flow has a radial velocity directed outwards in said space with a magnitude larger than zero at every location in said space.

Lithographic apparatus comprising a gas flushing system

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Eindhoven, Netherlands

Pieter Klaas De Bokx