Marina Biotech, Inc.

Genevant Sciences Gmbh

Phaserx, Inc.

Pierrot Harvie

Mary Gallagher Prieve

Michael E Houston, Jr

Steven C Quay

Sean D Monahan

Roger C Adami

Shaguna Seth

Kathy L Fosnaugh

Renata Fam

Charbel Diab

Maher Qabar

Michael S DeClue

Anna Galperin

Debashish Roy

Amber E Paschal

Russell N Johnson

Michael V Templin

Rachel E Johns

Michael E Houston

Barry A Polisky

Jaya S Giyanani

Michael Houston

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Block copolymers

Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. Also disclosed are related compositions and delivery systems.

Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells

Nucleic acid constructs and methods of using the same

This disclosure provides a range of tyrosine amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

Tyrosine-based lipids for delivery of therapeutics

This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

Arginine-based lipids for delivery of therapeutics

Amino acid lipids and uses thereof

Growing community of inventors

Bothell, WA, United States of America

Pierrot Harvie