Sanofi-aventis

Pierrick Rochard

Claudine Serradeil-Le Gal

Gilles Courtemanche

Pierre Despeyroux

Evelyne Fontaine

Loïc Foulon

Gérard Valette

Claudine Serradeil Le Gal

The present invention is directed to a compound of formula (I): wherein Ar, Ar, Ar, R1 and T are as defined herein, its preparation, pharmaceutical composition and uses as orexin 2 receptor antagonist.

Sulfonamide derivatives, preparation thereof and use thereof as antagonists of orexin 2 receptors

Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barr&#xe9; syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

Sulphonamide derivatives, their preparation and their therapeutic application

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Antony, France

Pierrick Rochard