Université´de Rouen

Advanced Accelerator Applications Sa

Centre National De La Recherche Scientifique

Biomerieux Sa

Quidd

Advanced Accelerator Applications

Pierre-Yves Renard

Anthony Romieu

Cedric Bouteiller

Davide Camporese

Thomas Priem

Sylvain Orenga

Marc Massonneau

Arnaud Chevalier

Benoit Roubinet

Valérie Chalansonnet

Cédric Bouteiller

Nucleophile-reactive sulfonated compounds used as precursors to (radio)labelled (bio)molecules are produced by pre-introduction of a nucleophilic compound R* through an unusual nucleophile-induced ring-opening reaction of the sultone moiety of the precursor. The precursors and compounds conform to respective formulae (Ip) and (I): Also disclosed are methods for producing these precursors and compounds, as well as for conjugation of these compounds with (bio)molecules, and to the drugs obtained by this method.

Nucleophile-reactive sulfonated compounds for the (radio)labelling of (bio)molecules; precursors and conjugates thereof

Nucleophile-reactive sulfonated compounds for the (radio)labelling of (bio) molecules; precursors and conjugates thereof

The invention relates to fluorescent/fluorogenic probes of formula (I&#x2033;) or (II&#x2033;): wherein Z is chosen between:  It also relates to the use of these fluorescent/fluorogenic probes, for the detection of an enzyme activity, notably in order to identify/discriminate microorganisms in function of their ability to express particular enzyme activities.

Fluorogenic/fluorescent probes derivative from sulfoxanthene, and use thereof

The invention concerns novel 1,2-dioxetane derivatives of general formula (I) as defined in the description, capable of emitting a detectable luminescent signal, their use in a method for detecting and/or quantizing a physical, chemical or biological, in particular enzymatic, phenomenon, as well as a kit for implementing said method.

Light-emitting biomarker

Growing community of inventors

Paris, France

Pierre-Yves Renard