Alliance Pharmaceutical Corp.

Application Et Transferts De Technologies Avancees

Pierre Vierling

Jean G Riess

Alain Milius

Jacques Greiner

Sylvie Gaentzler

Frederic Guillod

Nathalie Garelli

Marie-Pierre Krafft

Francois Jeanneaux

Catherine Santaella

Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to the formulae: ##STR1## wherein V is O or S;

Perfluoroalkylated amphiphilic phosphorus compounds: preparation and

Perfluorinated amphiphilic phosphorous compounds: liposomal compositions

Fluoroalkylated amphiphilic ligands are derived from aromatic amines of the bipyridine (I) or phenanthroline (II) types, and form complexes with platinum, palladium and ruthenium. ##STR1## In formulae (I) and (II), R.sup.1 and R.sup.2 are independently a hydrogen atom, or a fluoroalkylated or hydrocarbon chain, provided at least one of R.sup.1 and R.sup.2 is a fluoroalkylated chain, and W represents a methylene, ester, ether, carbonyl or amide group. Fluoroalkylated ligands (I or II) and their complexes can be included in preparations comprising emulsions, dispersions, gels, or microemulsions, particularly in preparations for therapeutic use.

Fluoroalkylated amphiphilic ligands, their metallic complexes and their

Fluoroalkylated amphiphilic ligands of bipyridine (I) that form complexes with platinum and palladium are disclosed. ##STR1## wherein R.sup.1 and R.sup.2 are independently a hydrogen atom, or a fluoroalkylated or hydrocarbon chain, provided at least one of R.sup.1 and R.sup.2 is a fluoroalkylated chain, and W represents a methylene, ester, ether, carbonyl or amide group.

Fluoroalkylated amphiphilic ligands and their metallic complexes

Compounds of the general formula: ##STR1## are useful as surfactants in the preparation of fluorocarbon emulsions, which can be used as oxygen-carrying blood substitutes, and for many other therapeutic and diagnostic applications. They are further useful in liposomal formulations which are themselves therapeutic agents or provide a vehicle for such agents.

Fluorine and phosphorous-containing amphiphilic molecules with

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Falicon, France

Pierre Vierling