Methylgene, Inc.

Envivo Pharmaceuticals, Inc.

Forum Pharmaceuticals, Inc.

Pierre Tessier

Silvana Leit

David Smil

Oscar Miguel Moradei

Sylvie Frechette

Yves Andre Chantigny

Robert Deziel

Patrick Beaulieu

John Mancuso

Tammy Mallais

Richard Chesworth

Gideon Shapiro

Arkadii Vaisburg

Jeffrey M Besterman

Alain Ajamian

Isabelle Paquin

Robert Déziel

Celia Dominguez

Simon Roy

Roger Machaalani

Oscar Moradei

Tammy C Mallais

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.

Dibenzo[b,f][1,4]oxazepin-11-yl-N-hydroxybenzamides as HDAC inhibitors

This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.

Inhibitors of histone deacetylase

This invention relates to compounds and methods for the inhibition of HDAC enzymatic activity. More particularly, the invention provides for compounds of formula (I), (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein L, M, n, R, W, X and Y are as defined in the specification. 

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

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Hawkesbury, Canada

Pierre Tessier