Ethypharm, Inc.

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Universitë De Bordeaux

Institut Polytechnique De Bordeaux

Universite Paris Cité

Paris Sciences Et Lettres

Ecole Nationale Superieure D'arts Et Metiers

Nexbiome Therapeutics

UniversitÉ De Paris

Ecole Nationale Superieure D'arts Et Metiers (ensam)

Pierre Tchoreloff

Bernard Leclerc

Adrien Nivoliez

Laurent Bertocchi

Pascal Bigey

Christine Charrueau

Virginie Escriou

Guillaume Benoist

Guy Couaraze

Patrick Sanial

Vincent Mazel

Claudia Thoral

Virginie Busignies

Virginie Busignies-goddin

The invention relates to a process for the manufacture of a tablet comprising a nucleic acid vector.

Nucleic acid vector tablets

The disclosure relates to a mucoadhesive sustained-release vaginal tablet including at least one probiotic strain of the genuscompressed with an excipient suitable for conferring upon the tablet the properties of vaginal wall mucoadhesion and sustained release.

Mucoadhesive sustained-release vaginal tablet

The invention concerns a microgranule tablet comprising a low dose of active principle containing a directly compressible diluent. The invention is characterized in that the directly compressible diluent consists exclusively of neutral microgranules, and the active principle is set on the neutral microgranules and is not coated with an agent designed to modify its release or mask its taste.

Low-dose tablets and preparation method

The invention relates to low-dose tablets obtained by directly compressing microgranules essentially constituted of a neutral support covered by a polymeric layer containing at least one pharmaceutically acceptable polymer and permitting the modified release of active substances in an aqueous medium, to which an active layer containing at least one active substance is applied. The inventive tablets advantageously exhibit a matrix effect similar to that obtained with conventional matrix tablets that depends on the nature of the polymer(s) used for the constitution of the polymeric layer. This matrix effect makes it possible to modify the release profile of the transported active substance based on the type of the polymer used. These tablets are particularly suited for realizing low-dose tablets. The invention also relates to a method for producing these tablets and to the use thereof, particularly for administering active substances in low to very low doses.

Low-dose tablets having a network of polymers

Growing community of inventors

Gradignan, France

Pierre Tchoreloff