Institut National De La Sante Et De La Recherche Medicale

Agence Nationale De Valorisation De La Recherche (anvar)

Agence Nationale De Valorisation De La Recherche

Pierre Tambourin

Francoise Wendling

Luc Montagnier

Jean-Claude Chermann

Emile R Bisagni

Christian Rivalle

Claire Ducrocq

Martine Charon

Paule Varlet

Michele Souyri

Isabelle Vigon

Jean-Francios Penciolelli

Sylvie Gisselbrecht

Jacqueline Gruest

Alain Civier

Rosette Lidereau

Polypeptide of a growth factor receptor family, having a specific sequence and presenting all or part of the following properties: it encourages and/or is involved in the proliferation and/or differentiation of hematopoietic cell lines when obtained from the MPLV retrovirus; it is capable of acting as a hematopoietic growth factor receptor; it is recognized by antibodies directed against it. Polypeptides similar to the above. Applications in the diagnosis of the expression of said ligand polypeptide.

Methods for detection of molecules with affinity for MPL polypeptides

Nucleic acid encoding polypeptide of a growth factor receptor family

The invention relates to compounds of formula: ##STR1## wherein R'.sub.1 =H, OH or an alkyl group, preferably a lower alkyl group, alkylthio or alkoxy, an halogen or an amino group,

Dipyrido (4,3-B) (3,4-F) indoles, process for obtaining them,

The novel derivatives correspond to the general formula: ##STR1## in which R.sub.1 is a Y--(CH.sub.2).sub.n --NR.sub.4 R.sub.5 group, where Y represents a single bond or the group ##STR2## R.sub.4 and R.sub.5, identical or different, are hydrogen or an alkyl radical, preferably a lower alkyl, or again form together a ring which can include heteroatoms, in particular nitrogen atoms. n is a number ranging from 1 to 10, notably from 2 to 7, R.sub.2 is a hydrogen atom, a lower alkyl group or an aralkyl group in which the alkyl substituent is a lower alkyl group, and R.sub.3 is a hydrogen atom or a CH.sub.3 group useful for the treatment of leukemias.

Pyrido (4,3-B) carbazoles substituted in the 1 position by a polyamine

Dipyrido [4,3-b] [3,4-f] indoles and process for obtaining them

Growing community of inventors

Orsay les Ulis, France

Pierre Tambourin