Institut National De La Sante Et De La Recherche Medicale

Adir Et Compagnie

Societe Civile Bioprojet

Societe Civile Brioprojet

Pierre Sokoloff

Jean-Charles Schwartz

Fabrice Garrido

Jeanne-Marie Lecomte

Camille-Georges Wermuth

Mark Millan

Jean-Louis Peglion

Bertrand Goument

Joel Vian

Marie-Pascale Martres

André Mann

Bruno Giros

Valerie Audinot

Didier Rognan

Catherine Pilon

Angéle Schoenfelder

Giros Bruno

Val Erie Audinot

The invention relates to 3,4-dihydro-2-naphthamide derivatives of formula (I), pharmaceutical compositions containing them and their therapeutic applications as partial agonists or antagonists of the dopamine D3 receptor for the treatment of neuropsychological disorders.

3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands

The invention relates to 2-naphthamide derivatives, in the form of bases or of salts, corresponding to the following general formula (I): ##STR1## in which: the Z-Y entity represents an N--CH.sub.2, C.dbd.CH or CH--CH.sub.2 group;

2-naphthamide derivatives and their therapeutic applications

The invention related to 2-naphthamide derivatives, in the form of bases or of salts, corresponding to the following general formula (I): ##STR1## in which: the Z--Y entity represents an N--CH.sub.2, C.dbd.CH or CH--CH.sub.2 group;

2-Naphthamide derivatives and their therapeutic applications

New compounds of formula: ##STR1## wherein A-B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.

Tetracyclic piperidine and 1,4-oxazine compounds

New compounds of formula: ##STR1## wherein A--B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.

Tetracyclic 1,4-oxazine compounds

The new naphthamide derivatives according to the invention are characterized in that they correspond to the general formula (I), ##STR1## where X: represents either a hydrogen atom, or a chlorine or bromine atom, or an amino or aminoalkyl group, an aminosulphamoyl group, a sulphur-containing group such as thiocyanate, alkylthio, alkylsulphinyl or alkylsulphonyl, or a methoxy group, or a nitro group, or a cyano group, or an electron-attracting group;

Naphthamide derivatives

Polypeptides having a dopaminergic receptor activity, nucleic acids

Growing community of inventors

Le Plessis Bouchard, France

Pierre Sokoloff