The Hartz Mountain Corporation

Kimberly-Clark Worldwide, Inc.

Summit Vetpharm, LLC

Pierre R Joseph

Ian Cottrell

Christine M Monro

Albert Ahn

Richard Fisher

Scott W Wenzel

Corey Thomas Cunningham

Thomas Gerard Shannon

Lisa Ann Flugge-Berendes

Benjamin Joseph Kruchoski

Michael William Lytwyn

Jeffrey R Seidling

Foamable compositions are disclosed. The compositions contain one or more active ingredients combined with a foaming agent and optionally one or more surface tension adjusting agents. The foaming agent may comprise, for instance, a derivatized dimethicone. The surface tension adjusting agent, on the other hand, comprises a chemical species that either increases or decreases the surface tension of the composition within a desired range so that the composition is readily foamable. In this manner, active ingredients can be incorporated into the compositions that are typically hard to foam. Such ingredients include cleaning solvents and various skin care agents. Of particular advantage, foamable compositions can be formulated in accordance with the present disclosure that contain relatively small amounts of water such as less than about 20 percent by weight, such as less than about 10 percent by weight. In other embodiments, the composition can be completely anhydrous.

Foamable compositions

Provided is a temperature change composition including a neurosensory component; and a first phase change component having a first phase change temperature between about 15 degrees C. and about 40 degrees C. Also provided is a temperature change composition including an evaporative cooling component; and a first phase change component having a first phase change temperature. Also provided is a temperature change composition for cooling skin, the composition including a first phase change component having a first phase change temperature; and a second phase change component having a second phase change temperature different from the first phase change temperature.

Skin cooling compositions

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas dissolved in ethyl lactate.

High concentration dinotefuran formulations

A topical insecticide preparation is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The topical insecticide contains a combination of a first pyrethroid insecticide effective for killing fleas, a second pyrethroid insecticide effective for killing ticks, and an insect growth regulator (IGR). The topical insecticide preparation can be packaged together or packaged so that the first and second pyrethroid insecticides are stored separately prior to administration of the insecticide preparation to the animal. The combination of the first and second pyrethroid insecticides with an insect growth regulator results in an insecticide preparation formulated to have enhanced insecticidal activity against fleas and ticks compared to the effectiveness of the first and second insecticides used alone. Further, the combination of the first and second pyrethroid insecticides with an insect growth regulator produces an insecticide preparation having enhanced insecticidal activity against fleas and ticks while advantageously minimizing the total amount of insecticide needed for its effectiveness.

High concentration topical insecticides containing pyrethroids

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an insect growth regulator effective for killing fleas, flea larvae and flea eggs. The insecticide is formulated by dissolving an insecticidal (tetrahydro-3-furanyl) methylamine derivative or a chloronicotinyl insecticide and an insect growth regulator (IGR) in a solvent containing a quaternary ammonium salt to increase the solvency of the IGR component, thereby providing an insecticide having high insecticidal activity.

High concentration topical insecticide containing insect growth regulator

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. The insecticide contains an insecticide and an insect growth regulator effective for killing fleas, flea larvae and flea eggs. The insecticide is formulated by dissolving an insecticidal (tetrahydro-3-furanyl) methylamine derivative and an insect growth regulator (IGR) in a solvent containing a quaternary ammonium salt to increase the solvency of the IGR component, thereby providing an insecticide having high insecticidal activity.

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-&lcub;(tetrahydro-3-furanyl)methyl&rcub;-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas, dissolved in phenyl methanol or ethanol and ethyl lactate.

Growing community of inventors

Appleton, WI, United States of America

Pierre R Joseph